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Items: 1 to 20 of 74

1.

Radiomitigation and Tissue Repair Activity of Systemically Administered Therapeutic Peptide TP508 Is Enhanced by PEGylation.

McVicar SD, Rayavara K, Carney DH.

AAPS J. 2017 May;19(3):743-753. doi: 10.1208/s12248-016-0043-7. Epub 2017 Jan 17.

PMID:
28097629
2.

Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair.

Olszewska-Pazdrak B, McVicar SD, Rayavara K, Moya SM, Kantara C, Gammarano C, Olszewska P, Fuller GM, Sower LE, Carney DH.

Radiat Res. 2016 Aug;186(2):162-74. doi: 10.1667/RR14409.1. Epub 2016 Jul 7.

3.

Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.

Kantara C, Moya SM, Houchen CW, Umar S, Ullrich RL, Singh P, Carney DH.

Lab Invest. 2015 Nov;95(11):1222-33. doi: 10.1038/labinvest.2015.103. Epub 2015 Aug 17.

4.

Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia.

Olszewska-Pazdrak B, Carney DH.

J Vasc Res. 2013;50(3):186-96. doi: 10.1159/000348250. Epub 2013 Apr 16.

5.

Inorganic phosphate induces mammalian growth plate chondrocyte apoptosis in a mitochondrial pathway involving nitric oxide and JNK MAP kinase.

Zhong M, Carney DH, Jo H, Boyan BD, Schwartz Z.

Calcif Tissue Int. 2011 Feb;88(2):96-108. doi: 10.1007/s00223-010-9433-5. Epub 2010 Nov 23.

PMID:
21104071
6.

17β-Estradiol regulates rat growth plate chondrocyte apoptosis through a mitochondrial pathway not involving nitric oxide or MAPKs.

Zhong M, Carney DH, Boyan BD, Schwartz Z.

Endocrinology. 2011 Jan;152(1):82-92. doi: 10.1210/en.2010-0509. Epub 2010 Nov 10.

PMID:
21068162
7.

Thrombin peptide TP508 stimulates rapid nitric oxide production in human endothelial cells.

Olszewska-Pazdrak B, Hart-Vantassell A, Carney DH.

J Vasc Res. 2010;47(3):203-13. doi: 10.1159/000255963. Epub 2009 Nov 6.

8.

Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells.

Olszewska-Pazdrak B, Hein TW, Olszewska P, Carney DH.

Am J Physiol Cell Physiol. 2009 May;296(5):C1162-70. doi: 10.1152/ajpcell.00533.2008. Epub 2009 Feb 25.

9.

Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair?

Carney DH, Olszewska-Pazdrak B.

Expert Opin Pharmacother. 2008 Oct;9(15):2717-26. doi: 10.1517/14656566.9.15.2717 . Review.

PMID:
18803458
10.

Inhibition of phosphate-induced apoptosis in resting zone chondrocytes by thrombin peptide 508.

Zhong M, Carney DH, Ryaby JT, Schwartz Z, Boyan BD.

Cells Tissues Organs. 2009;189(1-4):56-9. doi: 10.1159/000152913. Epub 2008 Sep 1.

PMID:
18765928
11.

TP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia.

Fossum TW, Olszewska-Pazdrak B, Mertens MM, Makarski LA, Miller MW, Hein TW, Kuo L, Clubb F, Fuller GM, Carney DH.

J Cardiovasc Pharmacol Ther. 2008 Sep;13(3):214-25. doi: 10.1177/1074248408321468.

PMID:
18757834
12.

Thrombin peptide TP508 prevents nitric oxide mediated apoptosis in chondrocytes in the endochondral developmental pathway.

Zhong M, Wike LJ, Ryaby JT, Carney DH, Boyan BD, Schwartz Z.

Biochim Biophys Acta. 2008 Jan;1783(1):12-22. Epub 2007 Nov 20.

13.

Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study.

Fife C, Mader JT, Stone J, Brill L, Satterfield K, Norfleet A, Zwernemann A, Ryaby JT, Carney DH.

Wound Repair Regen. 2007 Jan-Feb;15(1):23-34.

PMID:
17244316
14.

Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues.

Ryaby JT, Sheller MR, Levine BP, Bramlet DG, Ladd AL, Carney DH.

J Bone Joint Surg Am. 2006 Nov;88 Suppl 3:132-9. Review.

PMID:
17079379
15.

Methods: a comparative analysis of radiography, microcomputed tomography, and histology for bone tissue engineering.

Hedberg EL, Kroese-Deutman HC, Shih CK, Lemoine JJ, Liebschner MA, Miller MJ, Yasko AW, Crowther RS, Carney DH, Mikos AG, Jansen JA.

Tissue Eng. 2005 Sep-Oct;11(9-10):1356-67.

PMID:
16259591
16.

In vitro release of plasmid DNA from oligo(poly(ethylene glycol) fumarate) hydrogels.

Kasper FK, Seidlits SK, Tang A, Crowther RS, Carney DH, Barry MA, Mikos AG.

J Control Release. 2005 Jun 2;104(3):521-39. Epub 2005 Apr 26.

PMID:
15911051
17.

Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis.

Wang H, Li X, Tomin E, Doty SB, Lane JM, Carney DH, Ryaby JT.

J Orthop Res. 2005 May;23(3):671-9. Epub 2004 Dec 15.

18.

In vivo degradation of porous poly(propylene fumarate)/poly(DL-lactic-co-glycolic acid) composite scaffolds.

Hedberg EL, Kroese-Deutman HC, Shih CK, Crowther RS, Carney DH, Mikos AG, Jansen JA.

Biomaterials. 2005 Aug;26(22):4616-23. Epub 2005 Jan 18.

PMID:
15722131
19.

Effect of varied release kinetics of the osteogenic thrombin peptide TP508 from biodegradable, polymeric scaffolds on bone formation in vivo.

Hedberg EL, Kroese-Deutman HC, Shih CK, Crowther RS, Carney DH, Mikos AG, Jansen JA.

J Biomed Mater Res A. 2005 Mar 15;72(4):343-53.

PMID:
15666357
20.

Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis.

Li G, Ryaby JT, Carney DH, Wang H.

J Orthop Res. 2005 Jan;23(1):196-202.

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