Send to

Choose Destination

See 1 citation found by title matching your search:

Traffic. 2018 Mar;19(3):166-181. doi: 10.1111/tra.12544. Epub 2018 Feb 12.

Cargo crowding at actin-rich regions along axons causes local traffic jams.

Author information

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
Neurobiology, National Centre for Biological Sciences, Bangalore, India.
The Institute of Mathematical Sciences, CIT Campus, Chennai, India.
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri.
Homi Bhabha National Institute, Training School Complex, Mumbai, India.


Steady axonal cargo flow is central to the functioning of healthy neurons. However, a substantial fraction of cargo in axons remains stationary up to several minutes. We examine the transport of precursors of synaptic vesicles (pre-SVs), endosomes and mitochondria in Caenorhabditis elegans touch receptor neurons, showing that stationary cargo are predominantly present at actin-rich regions along the neuronal process. Stationary vesicles at actin-rich regions increase the propensity of moving vesicles to stall at the same location, resulting in traffic jams arising from physical crowding. Such local traffic jams at actin-rich regions are likely to be a general feature of axonal transport since they also occur in Drosophila neurons. Repeated touch stimulation of C. elegans reduces the density of stationary pre-SVs, indicating that these traffic jams can act as both sources and sinks of vesicles. This suggests that vesicles trapped in actin-rich regions are functional reservoirs that may contribute to maintaining robust cargo flow in the neuron. A video abstract of this article can be found at: Video S1; Video S2.


Caenorhabditis elegans; Drosophila melanogaster; actin; axonal transport; neuronal stimulation; physical crowding; precursors of synaptic vesicles; reservoirs; stationary cargo; stationary vesicles; touch receptor neurons; traffic jams

Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center