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Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase.

DeColli AA, Zhang X, Heflin KL, Jordan F, Freel Meyers CL.

Biochemistry. 2019 Dec 10;58(49):4970-4982. doi: 10.1021/acs.biochem.9b00878. Epub 2019 Nov 26.


X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.

Chen PY, DeColli AA, Freel Meyers CL, Drennan CL.

J Biol Chem. 2019 Aug 16;294(33):12405-12414. doi: 10.1074/jbc.RA119.009321. Epub 2019 Jun 25.


Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies.

Hobson JJ, Al-Khouja A, Curley P, Meyers D, Flexner C, Siccardi M, Owen A, Meyers CF, Rannard SP.

Nat Commun. 2019 Mar 29;10(1):1413. doi: 10.1038/s41467-019-09354-z.


Enamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents.

Bartee D, Sanders S, Phillips PD, Harrison MJ, Koppisch AT, Freel Meyers CL.

ACS Infect Dis. 2019 Mar 8;5(3):406-417. doi: 10.1021/acsinfecdis.8b00307. Epub 2019 Jan 18.


Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism.

Bartee D, Freel Meyers CL.

Acc Chem Res. 2018 Oct 16;51(10):2546-2555. doi: 10.1021/acs.accounts.8b00321. Epub 2018 Sep 11.


Targeting the Unique Mechanism of Bacterial 1-Deoxy-d-xylulose-5-phosphate Synthase.

Bartee D, Freel Meyers CL.

Biochemistry. 2018 Jul 24;57(29):4349-4356. doi: 10.1021/acs.biochem.8b00548. Epub 2018 Jul 6.


Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2- C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens.

Bartee D, Wheadon MJ, Freel Meyers CL.

J Org Chem. 2018 Sep 7;83(17):9580-9591. doi: 10.1021/acs.joc.8b00686. Epub 2018 Jun 11.


Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria.

DeColli AA, Nemeria NS, Majumdar A, Gerfen GJ, Jordan F, Freel Meyers CL.

J Biol Chem. 2018 Jul 13;293(28):10857-10869. doi: 10.1074/jbc.RA118.001980. Epub 2018 May 21.


Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.

Sanders S, Bartee D, Harrison MJ, Phillips PD, Koppisch AT, Freel Meyers CL.

PLoS One. 2018 May 17;13(5):e0197638. doi: 10.1371/journal.pone.0197638. eCollection 2018.


A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.

Afanador GA, Guerra AJ, Swift RP, Rodriguez RE, Bartee D, Matthews KA, Schön A, Freire E, Freel Meyers CL, Prigge ST.

Mol Microbiol. 2017 Nov;106(3):439-451. doi: 10.1111/mmi.13776. Epub 2017 Sep 8.


Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.

Zhou J, Yang L, DeColli A, Freel Meyers C, Nemeria NS, Jordan F.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9355-9360. doi: 10.1073/pnas.1619981114. Epub 2017 Aug 14.


Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.

Sanders S, Vierling RJ, Bartee D, DeColli AA, Harrison MJ, Aklinski JL, Koppisch AT, Freel Meyers CL.

ACS Infect Dis. 2017 Jul 14;3(7):467-478. doi: 10.1021/acsinfecdis.6b00168. Epub 2017 Jun 21.


In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents.

Rajoli RKR, Back DJ, Rannard S, Meyers CF, Flexner C, Owen A, Siccardi M.

Clin Pharmacokinet. 2018 Feb;57(2):255-266. doi: 10.1007/s40262-017-0557-x.


Competence of Thiamin Diphosphate-Dependent Enzymes with 2'-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin.

Nemeria NS, Shome B, DeColli AA, Heflin K, Begley TP, Meyers CF, Jordan F.

Biochemistry. 2016 Feb 23;55(7):1135-48. doi: 10.1021/acs.biochem.5b01300. Epub 2016 Feb 8.


Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase.

Bartee D, Morris F, Al-Khouja A, Freel Meyers CL.

Chembiochem. 2015 Aug 17;16(12):1771-81. doi: 10.1002/cbic.201500119. Epub 2015 Jul 15.


Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).

Armstrong CM, Meyers DJ, Imlay LS, Freel Meyers C, Odom AR.

Antimicrob Agents Chemother. 2015 Sep;59(9):5511-9. doi: 10.1128/AAC.00602-15. Epub 2015 Jun 29.


Pharmacological activation of myosin II paralogs to correct cell mechanics defects.

Surcel A, Ng WP, West-Foyle H, Zhu Q, Ren Y, Avery LB, Krenc AK, Meyers DJ, Rock RS, Anders RA, Freel Meyers CL, Robinson DN.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1428-33. doi: 10.1073/pnas.1412592112. Epub 2015 Jan 20.


Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV.

Rajoli RK, Back DJ, Rannard S, Freel Meyers CL, Flexner C, Owen A, Siccardi M.

Clin Pharmacokinet. 2015 Jun;54(6):639-50. doi: 10.1007/s40262-014-0227-1.


Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.

Afanador GA, Matthews KA, Bartee D, Gisselberg JE, Walters MS, Freel Meyers CL, Prigge ST.

Mol Microbiol. 2014 Oct;94(1):156-71. doi: 10.1111/mmi.12753. Epub 2014 Sep 1.


Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites.

Hain AU, Bartee D, Sanders NG, Miller AS, Sullivan DJ, Levitskaya J, Meyers CF, Bosch J.

J Med Chem. 2014 Jun 12;57(11):4521-31. doi: 10.1021/jm401675a. Epub 2014 May 19.

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