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Nano Lett. 2012 Apr 11;12(4):1831-8. doi: 10.1021/nl204064s. Epub 2012 Mar 28.

Carbon nanotubes promote growth and spontaneous electrical activity in cultured cardiac myocytes.

Author information

1
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.

Abstract

Nanoscale manipulations of the extracellular microenvironment are increasingly attracting attention in tissue engineering. Here, combining microscopy, biological, and single-cell electrophysiological methodologies, we demonstrate that neonatal rat ventricular myocytes cultured on substrates of multiwall carbon nanotubes interact with carbon nanotubes by forming tight contacts and show increased viability and proliferation. Furthermore, we observed changes in the electrophysiological properties of cardiomyocytes, suggesting that carbon nanotubes are able to promote cardiomyocyte maturation.

PMID:
22432413
DOI:
10.1021/nl204064s
[Indexed for MEDLINE]

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