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Items: 1 to 20 of 121


Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins.

Ruff JS, Saffarini RB, Ramoz LL, Morrison LC, Baker S, Laverty SM, Tvrdik P, Capecchi MR, Potts WK.

PLoS One. 2017 Apr 5;12(4):e0174975. doi: 10.1371/journal.pone.0174975. eCollection 2017.


Derivation of Transgene-Free Rat Induced Pluripotent Stem Cells Approximating the Quality of Embryonic Stem Cells.

Li S, Lan H, Men H, Wu Y, Li N, Capecchi MR, Bryda EC, Wu S.

Stem Cells Transl Med. 2017 Feb;6(2):340-351. doi: 10.5966/sctm.2015-0390. Epub 2016 Sep 13.


piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice.

Xu C, Qi X, Du X, Zou H, Gao F, Feng T, Lu H, Li S, An X, Zhang L, Wu Y, Liu Y, Li N, Capecchi MR, Wu S.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):722-727. doi: 10.1073/pnas.1615735114. Epub 2017 Jan 6.


Modeling synovial sarcoma metastasis in the mouse: PI3'-lipid signaling and inflammation.

Barrott JJ, Kafchinski LA, Jin H, Potter JW, Kannan SD, Kennedy R, Mosbruger T, Wang WL, Tsai JW, Araujo DM, Liu T, Capecchi MR, Lazar AJ, Jones KB.

J Exp Med. 2016 Dec 12;213(13):2989-3005. Epub 2016 Nov 9.


Genome-wide piggyBac transposon mediated screening reveals genes related to reprogramming.

Zhang X, Wei X, Wu Y, Wang Y, Tan C, Hu X, Li N, Capecchi MR, Wu S.

Protein Cell. 2017 Feb;8(2):134-139. doi: 10.1007/s13238-016-0332-z. No abstract available.


Derivation of Transgene-Free Rat Induced Pluripotent Stem Cells Approximating the Quality of Embryonic Stem Cells.

Li S, Lan H, Men H, Wu Y, Li N, Capecchi MR, Bryda EC, Wu S.

Stem Cells Transl Med. 2016 Sep 13. pii: sctm.2015-0390. [Epub ahead of print]


Efficient generation of selection-gene-free rat knockout models by homologous recombination in ES cells.

Lan H, Li S, Guo Z, Men H, Wu Y, Li N, Bryda EC, Capecchi MR, Wu S.

FEBS Lett. 2016 Oct;590(19):3416-3424. doi: 10.1002/1873-3468.12388. Epub 2016 Sep 18.


The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.

Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR.

Oncogene. 2016 Sep 22;35(38):5021-32. doi: 10.1038/onc.2016.38. Epub 2016 Mar 7.


ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.

Capecchi MR, Pozner A.

Nat Commun. 2015 Nov 19;6:8763. doi: 10.1038/ncomms9763.


Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice.

Prigge JR, Hoyt TR, Dobrinen E, Capecchi MR, Schmidt EE, Meissner N.

J Immunol. 2015 Dec 1;195(11):5347-57. doi: 10.4049/jimmunol.1501553. Epub 2015 Oct 30.


Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling.

Carroll LS, Capecchi MR.

Development. 2015 Dec 1;142(23):4056-67. doi: 10.1242/dev.128298. Epub 2015 Oct 12.


β-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition.

Barrott JJ, Illum BE, Jin H, Zhu JF, Mosbruger T, Monument MJ, Smith-Fry K, Cable MG, Wang Y, Grossmann AH, Capecchi MR, Jones KB.

Oncotarget. 2015 Sep 8;6(26):22758-66.


Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.

Pozner A, Xu B, Palumbos S, Gee JM, Tvrdik P, Capecchi MR.

Front Mol Neurosci. 2015 May 8;8:12. doi: 10.3389/fnmol.2015.00012. eCollection 2015.


Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation.

Gee JM, Gibbons MB, Taheri M, Palumbos S, Morris SC, Smeal RM, Flynn KF, Economo MN, Cizek CG, Capecchi MR, Tvrdik P, Wilcox KS, White JA.

Front Mol Neurosci. 2015 Apr 15;8:10. doi: 10.3389/fnmol.2015.00010. eCollection 2015.


Response: Contributions of the Myf5-independent lineage to myogenesis.

Haldar M, Karan G, Watanabe S, Guenther S, Braun T, Capecchi MR.

Dev Cell. 2014 Dec 8;31(5):539-41. doi: 10.1016/j.devcel.2014.11.010.


Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment.

Goodwin ML, Jin H, Straessler K, Smith-Fry K, Zhu JF, Monument MJ, Grossmann A, Randall RL, Capecchi MR, Jones KB.

Cancer Cell. 2014 Dec 8;26(6):851-62. doi: 10.1016/j.ccell.2014.10.003. Epub 2014 Nov 26.


The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.

Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB.

Oncogene. 2015 Aug 6;34(32):4278-84. doi: 10.1038/onc.2014.354. Epub 2014 Oct 27.


Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS.

Nat Med. 2014 Nov;20(11):1289-300. doi: 10.1038/nm.3695. Epub 2014 Oct 26.


Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse.

Gee JM, Smith NA, Fernandez FR, Economo MN, Brunert D, Rothermel M, Morris SC, Talbot A, Palumbos S, Ichida JM, Shepherd JD, West PJ, Wachowiak M, Capecchi MR, Wilcox KS, White JA, Tvrdik P.

Neuron. 2014 Sep 3;83(5):1058-72. doi: 10.1016/j.neuron.2014.07.024. Epub 2014 Aug 21.


Lineage of origin in rhabdomyosarcoma informs pharmacological response.

Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C.

Genes Dev. 2014 Jul 15;28(14):1578-91. doi: 10.1101/gad.238733.114.

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