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Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.

Moghaddas F, Zeng P, Zhang Y, Schützle H, Brenner S, Hofmann SR, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna SW, Czabotar PE, Wicks IP, De Nardo D, Hedrich CM, Zeng H, Masters SL.

J Allergy Clin Immunol. 2018 Dec;142(6):1956-1967.e6. doi: 10.1016/j.jaci.2018.04.033. Epub 2018 May 17.


Introduction: Autoinflammatory Syndromes Special Issue-hidden mysteries in the corners of autoinflammation.

Canna SW, Goldbach-Mansky R.

Int Immunol. 2018 Apr 25;30(5):181-182. doi: 10.1093/intimm/dxy022. No abstract available.


Convergent pathways of the hyperferritinemic syndromes.

Schulert GS, Canna SW.

Int Immunol. 2018 Apr 25;30(5):195-203. doi: 10.1093/intimm/dxy012.


Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.

Weiss ES, Girard-Guyonvarc'h C, Holzinger D, de Jesus AA, Tariq Z, Picarsic J, Schiffrin EJ, Foell D, Grom AA, Ammann S, Ehl S, Hoshino T, Goldbach-Mansky R, Gabay C, Canna SW.

Blood. 2018 Mar 29;131(13):1442-1455. doi: 10.1182/blood-2017-12-820852. Epub 2018 Jan 11.


A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease.

Aeschlimann FA, Batu ED, Canna SW, Go E, Gül A, Hoffmann P, Leavis HL, Ozen S, Schwartz DM, Stone DL, van Royen-Kerkof A, Kastner DL, Aksentijevich I, Laxer RM.

Ann Rheum Dis. 2018 May;77(5):728-735. doi: 10.1136/annrheumdis-2017-212403. Epub 2018 Jan 9.


The NLRC4 Inflammasome.

Duncan JA, Canna SW.

Immunol Rev. 2018 Jan;281(1):115-123. doi: 10.1111/imr.12607. Review.


NLRC4 inflammasomopathies.

Romberg N, Vogel TP, Canna SW.

Curr Opin Allergy Clin Immunol. 2017 Dec;17(6):398-404. doi: 10.1097/ACI.0000000000000396. Review.


No shortcuts: new findings reinforce why nuance is the rule in genetic autoinflammatory syndromes.

Tsoukas P, Canna SW.

Curr Opin Rheumatol. 2017 Sep;29(5):506-515. doi: 10.1097/BOR.0000000000000422. Review.



Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM.

J Allergy Clin Immunol. 2017 Jul;140(1):316-317. doi: 10.1016/j.jaci.2017.03.016. Epub 2017 Apr 29. No abstract available.


Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization.

Canna SW, Shi G, Gery I, Sen HN.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1764-1765. doi: 10.1167/iovs.17-21697. No abstract available.


IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation.

Rood JE, Canna SW, Weaver LK, Tobias JW, Behrens EM.

J Leukoc Biol. 2017 Apr;101(4):1037-1044. doi: 10.1189/jlb.3A0916-221RR. Epub 2016 Dec 29.


Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM.

J Allergy Clin Immunol. 2017 May;139(5):1698-1701. doi: 10.1016/j.jaci.2016.10.022. Epub 2016 Nov 19. No abstract available.


Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis.

Das R, Guan P, Sprague L, Verbist K, Tedrick P, An QA, Cheng C, Kurachi M, Levine R, Wherry EJ, Canna SW, Behrens EM, Nichols KE.

Blood. 2016 Mar 31;127(13):1666-75. doi: 10.1182/blood-2015-12-684399. Epub 2016 Jan 29.


Editorial: 21st Century Storm Chasers: Defining Macrophage Activation Syndrome.

Canna SW, Nigrovic PA.

Arthritis Rheumatol. 2016 Mar;68(3):557-60. doi: 10.1002/art.39329. No abstract available.


New monogenic autoinflammatory diseases--a clinical overview.

Canna SW, Goldbach-Mansky R.

Semin Immunopathol. 2015 Jul;37(4):387-94. doi: 10.1007/s00281-015-0493-5. Epub 2015 May 12. Review.


Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling.

de Jesus AA, Canna SW, Liu Y, Goldbach-Mansky R.

Annu Rev Immunol. 2015;33:823-74. doi: 10.1146/annurev-immunol-032414-112227. Epub 2015 Feb 20. Review.


An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.

Nat Genet. 2014 Oct;46(10):1140-6. doi: 10.1038/ng.3089. Epub 2014 Sep 14.


Editorial: interferon-γ: friend or foe in systemic juvenile idiopathic arthritis and adult-onset Still's Disease?

Canna SW.

Arthritis Rheumatol. 2014 May;66(5):1072-6. doi: 10.1002/art.38362. No abstract available.


Brief report: alternative activation of laser-captured murine hemophagocytes.

Canna SW, Costa-Reis P, Bernal WE, Chu N, Sullivan KE, Paessler ME, Behrens EM.

Arthritis Rheumatol. 2014 Jun;66(6):1666-71.


Interferon-γ mediates anemia but is dispensable for fulminant toll-like receptor 9-induced macrophage activation syndrome and hemophagocytosis in mice.

Canna SW, Wrobel J, Chu N, Kreiger PA, Paessler M, Behrens EM.

Arthritis Rheum. 2013 Jul;65(7):1764-75. doi: 10.1002/art.37958.

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