Format

Send to

Choose Destination

See 1 citation found by title matching your search:

BMC Cancer. 2018 Nov 12;18(1):1096. doi: 10.1186/s12885-018-5013-2.

Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma.

Author information

1
Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 85, Lund, Sweden.
2
Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325017, China.
3
Department of Pathology, Skåne University Hospital, 221 85, Lund, Sweden.
4
Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 85, Lund, Sweden. roland.andersson@med.lu.se.

Abstract

BACKGROUND:

In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression was inversely correlated with patient survival. The aim of the study was to further validate the prognostic significance of CLCA1 in pancreatic cancer.

METHODS:

CLCA1 expression was evaluated with tissue microarrays and immunohistochemistry in 140 patients with pancreatic ductal adenocarcinoma that underwent surgical resection at Skåne University Hospital, Sweden. Kaplan-Meier and Cox proportional hazards modeling were used to explore the association between CLCA1 and clinicopathological factors and survival.

RESULTS:

CLCA1 expression was denoted as positive in 90 tumors (64.3%), with positive staining being limited to the tumor cells. There were no significant association between CLCA1 expression and established clinicopathological parameters. Low CLCA1 expression correlated significantly with shorter disease-free survival (11.9 vs 17.5 months, P = 0.042). Multivariable Cox regression analysis confirmed the results (HR 0.61, 95% CI-0.40-0.92, P = 0.019).

CONCLUSIONS:

Low CLCA1 expression is an independent factor of poor disease-free survival in pancreatic cancer.

KEYWORDS:

CLCA1; Calcium-activated chloride channel regulators; Pancreatic ductal adenocarcinoma; Survival

PMID:
30419838
PMCID:
PMC6233502
DOI:
10.1186/s12885-018-5013-2
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center