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Effects of conventional immunosuppressive treatment on CD244+ (CD28null) and FOXP3+ T cells in the inflamed muscle of patients with polymyositis and dermatomyositis.

Pandya JM, Loell I, Hossain MS, Zong M, Alexanderson H, Raghavan S, Lundberg IE, Malmström V.

Arthritis Res Ther. 2016 Apr 1;18:80. doi: 10.1186/s13075-016-0974-5.


Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen.

de Mare-Bredemeijer EL, Shi XL, Mancham S, van Gent R, van der Heide-Mulder M, de Boer R, Heemskerk MH, de Jonge J, van der Laan LJ, Metselaar HJ, Kwekkeboom J.

J Immunol. 2015 Aug 15;195(4):1838-48. doi: 10.4049/jimmunol.1500440. Epub 2015 Jul 13.


Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection.

Wang Y, Zhong H, Xie X, Chen CY, Huang D, Shen L, Zhang H, Chen ZW, Zeng G.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3883-92. doi: 10.1073/pnas.1501662112. Epub 2015 Jul 6.


CD244 is expressed on dendritic cells and regulates their functions.

Georgoudaki AM, Khodabandeh S, Puiac S, Persson CM, Larsson MK, Lind M, Hammarfjord O, Nabatti TH, Wallin RP, Yrlid U, Rhen M, Kumar V, Chambers BJ.

Immunol Cell Biol. 2015 Jul;93(6):581-90. doi: 10.1038/icb.2014.124. Epub 2015 Feb 3.


2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses.

Liu D, Krummey SM, Badell IR, Wagener M, Schneeweis LA, Stetsko DK, Suchard SJ, Nadler SG, Ford ML.

J Exp Med. 2014 Feb 10;211(2):297-311. doi: 10.1084/jem.20130902. Epub 2014 Feb 3.


Identification of CD244-expressing myeloid-derived suppressor cells in patients with active tuberculosis.

Yang B, Wang X, Jiang J, Zhai F, Cheng X.

Immunol Lett. 2014 Mar-Apr;158(1-2):66-72. doi: 10.1016/j.imlet.2013.12.003. Epub 2013 Dec 12.


Chicken SLAMF4 (CD244, 2B4), a receptor expressed on thrombocytes, monocytes, NK cells, and subsets of αβ-, γδ- T cells and B cells binds to SLAMF2.

Straub C, Neulen ML, Viertlboeck BC, Göbel TW.

Dev Comp Immunol. 2014 Feb;42(2):159-68. doi: 10.1016/j.dci.2013.09.007. Epub 2013 Sep 19.


Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells.

Pacheco Y, McLean AP, Rohrbach J, Porichis F, Kaufmann DE, Kavanagh DG.

J Immunol. 2013 Sep 1;191(5):2072-81. doi: 10.4049/jimmunol.1300435. Epub 2013 Aug 2.


Involvement of CD244 in regulating CD4+ T cell immunity in patients with active tuberculosis.

Yang B, Wang X, Jiang J, Cheng X.

PLoS One. 2013 Apr 30;8(4):e63261. doi: 10.1371/journal.pone.0063261. Print 2013.


Evolving role of 2B4/CD244 in T and NK cell responses during virus infection.

Waggoner SN, Kumar V.

Front Immunol. 2012 Dec 11;3:377. doi: 10.3389/fimmu.2012.00377. eCollection 2012.


2B4 (CD244) is involved in eosinophil adhesion and chemotaxis, and its surface expression is increased in allergic rhinitis after challenge.

El-Shazly AE, Henket M, Lefebvre PP, Louis R.

Int J Immunopathol Pharmacol. 2011 Oct-Dec;24(4):949-60.


Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells.

Schlaphoff V, Lunemann S, Suneetha PV, Jaroszewicz J, Grabowski J, Dietz J, Helfritz F, Bektas H, Sarrazin C, Manns MP, Cornberg M, Wedemeyer H.

PLoS Pathog. 2011 May;7(5):e1002045. doi: 10.1371/journal.ppat.1002045. Epub 2011 May 19.


Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein.

Margraf-Schönfeld S, Böhm C, Watzl C.

J Biol Chem. 2011 Jul 8;286(27):24142-9. doi: 10.1074/jbc.M111.225334. Epub 2011 May 23.


The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function.

Raziorrouh B, Schraut W, Gerlach T, Nowack D, Grüner NH, Ulsenheimer A, Zachoval R, Wächtler M, Spannagl M, Haas J, Diepolder HM, Jung MC.

Hepatology. 2010 Dec;52(6):1934-47. doi: 10.1002/hep.23936. Epub 2010 Nov 9.


Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse.

Wang N, Calpe S, Westcott J, Castro W, Ma C, Engel P, Schatzle JD, Terhorst C.

J Immunol. 2010 Nov 15;185(10):5683-7. doi: 10.4049/jimmunol.1001974. Epub 2010 Oct 20.


Mechanism of induction of NK activation by 2B4 (CD244) via its cognate ligand.

Sinha SK, Gao N, Guo Y, Yuan D.

J Immunol. 2010 Nov 1;185(9):5205-10. doi: 10.4049/jimmunol.1002518. Epub 2010 Sep 29.


Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells.

Kim EO, Kim N, Kim TJ, Kim K, Kim TW, Kumar V, Lee KM.

J Leukoc Biol. 2010 Oct;88(4):707-14. doi: 10.1189/jlb.0410198. Epub 2010 Jul 20.


Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus.

Ota Y, Kawaguchi Y, Takagi K, Tochimoto A, Kawamoto M, Katsumata Y, Gono T, Masuda I, Ikari K, Momohara S, Yamanaka H.

Mod Rheumatol. 2010 Oct;20(5):427-31. doi: 10.1007/s10165-010-0302-x.


Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus.

Kim JR, Mathew SO, Patel RK, Pertusi RM, Mathew PA.

Clin Exp Immunol. 2010 Jun;160(3):348-58. doi: 10.1111/j.1365-2249.2010.04116.x. Epub 2010 Mar 16.


High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease.

Enose-Akahata Y, Matsuura E, Oh U, Jacobson S.

PLoS Pathog. 2009 Dec;5(12):e1000682. doi: 10.1371/journal.ppat.1000682. Epub 2009 Dec 4.

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