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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 1
2003 3
2004 3
2005 2
2006 2
2007 8
2008 2
2009 4
2010 4
2011 14
2012 17
2013 10
2014 17
2015 14
2016 6
2017 17
2018 13
2019 13
2020 25
2021 30
2022 30
2023 18
2024 4

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233 results

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CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.
Chen J, Lin Y, Zheng S, Chen Q, Tang S, Zhong X. Chen J, et al. J Transl Med. 2023 Sep 6;21(1):600. doi: 10.1186/s12967-023-04478-9. J Transl Med. 2023. PMID: 37674204 Free PMC article.
RESULTS: Both genomic and protein expression showed that CBX3 was upregulated in ccRCC. Further functional analyses revealed that CBX3 played a crucial role in enhancing cell growth, migration, and EMT in vitro along with in vivo. ...Finally, immunoassays revealed t …
RESULTS: Both genomic and protein expression showed that CBX3 was upregulated in ccRCC. Further functional analyses revealed that …
Targeting CBX3 with a Dual BET/PLK1 Inhibitor Enhances the Antitumor Efficacy of CDK4/6 Inhibitors in Prostate Cancer.
Liang H, Yang C, Zeng R, Song Y, Wang J, Xiong W, Yan B, Jin X. Liang H, et al. Adv Sci (Weinh). 2023 Dec;10(36):e2302368. doi: 10.1002/advs.202302368. Epub 2023 Nov 10. Adv Sci (Weinh). 2023. PMID: 37949681 Free PMC article.
Furthermore, it is revealed that PLK1 phosphorylated CBX3 to enhance the interaction between RB1 and CBX3, and desensitize CRPC cells to CDK4/6 inhibitors. Given that BRD4 regulates CBX3 expression and PLK1 affects the binding between RB1 and CBX3, it …
Furthermore, it is revealed that PLK1 phosphorylated CBX3 to enhance the interaction between RB1 and CBX3, and desensitize CRP …
CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.
Zhang H, Yu H, Ren D, Sun Y, Guo F, Cai H, Zhou C, Zhou Y, Jin X, Wu H. Zhang H, et al. Int J Biol Sci. 2022 May 13;18(8):3484-3497. doi: 10.7150/ijbs.68995. eCollection 2022. Int J Biol Sci. 2022. PMID: 35637952 Free PMC article.
To date, the relationship between CBX3 and smoking in pancreatic cancer remains unknown. This study aimed to uncover the specific role and underlying mechanism of CBX3 in smoking-related pancreatic cancer. The bioinformatics analyses were conducted to identify CB …
To date, the relationship between CBX3 and smoking in pancreatic cancer remains unknown. This study aimed to uncover the specific rol …
CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis.
Zhao SP, Wang F, Yang M, Wang XY, Jin CL, Ji QK, Li S, Zhao XL. Zhao SP, et al. J Neurooncol. 2019 Oct;145(1):35-48. doi: 10.1007/s11060-019-03286-w. Epub 2019 Sep 9. J Neurooncol. 2019. PMID: 31502042
Besides, the CBX3 and CDKN1A expression levels in glioma U87 cells after transfected with CBX3-shRNA were gauged by qRT-PCR and Western blot. ...CBX3 can stimulate the growth of glioma U87 cells through targeting CDKN1A and CBX3 may become a novel targ …
Besides, the CBX3 and CDKN1A expression levels in glioma U87 cells after transfected with CBX3-shRNA were gauged by qRT-PCR an …
CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression.
Peng W, Shi S, Zhong J, Liang H, Hou J, Hu X, Wang F, Zhang J, Geng S, Sun X, Zhong D, Cui H. Peng W, et al. Oncogene. 2022 May;41(22):3051-3063. doi: 10.1038/s41388-022-02296-9. Epub 2022 Apr 22. Oncogene. 2022. PMID: 35459780
However, the molecular mechanism of CBX3 in glioblastoma multiforme (GBM) are unclear. Our study reported the identification of CBX3 as a potential therapeutic target for GBM. Briefly, we found that, CBX3 is significantly upregulated in GBM and reduces patien …
However, the molecular mechanism of CBX3 in glioblastoma multiforme (GBM) are unclear. Our study reported the identification of CB …
CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma.
Ma C, Nie XG, Wang YL, Liu XH, Liang X, Zhou QL, Wu DP. Ma C, et al. Mol Med Rep. 2019 May;19(5):4205-4212. doi: 10.3892/mmr.2019.10104. Epub 2019 Mar 28. Mol Med Rep. 2019. PMID: 30942427 Free PMC article.
In addition, the proliferation ability was blocked by the knockdown of CBX3 through the application of CBX3 siRNA, and CBX3 knockdown also led to increased apoptosis and cell cycle arrest at G0 and G1 phases in osteosarcoma cells. CBX3 is highly expres …
In addition, the proliferation ability was blocked by the knockdown of CBX3 through the application of CBX3 siRNA, and CBX3 …
CBX3 Promotes Gastric Cancer Progression and Affects Factors Related to Immunotherapeutic Responses.
Lin H, Lian J, Xia L, Guan G, You J. Lin H, et al. Cancer Manag Res. 2020 Oct 14;12:10113-10125. doi: 10.2147/CMAR.S271807. eCollection 2020. Cancer Manag Res. 2020. PMID: 33116867 Free PMC article.
BACKGROUND: Chromobox 3 (CBX3) is a member of the chromobox family proteins, which plays a critical role in tumor progression, but the exact function of CBX3 in gastric cancer remains unknown. ...CBX3 expression was further determined by immunohistochemistry …
BACKGROUND: Chromobox 3 (CBX3) is a member of the chromobox family proteins, which plays a critical role in tumor progression, but th …
CBX3 regulated by miR-139 promotes the development of HCC by regulating cell cycle progression.
Zhang P, Yang X, Zha Z, Zhu Y, Zhang G, Li G. Zhang P, et al. Cell Cycle. 2022 Aug;21(16):1740-1752. doi: 10.1080/15384101.2022.2068329. Epub 2022 Apr 26. Cell Cycle. 2022. PMID: 35471148 Free PMC article.
The biological functions of CBX3 in HCC were examined by in vitro experiments. Bioinformatics analysis, qRT-PCR and western blotting were performed to explore the mechanism of CBX3 in HCC. CBX3 mRNA was upregulated in HCC tissues, and overexpression of CBX …
The biological functions of CBX3 in HCC were examined by in vitro experiments. Bioinformatics analysis, qRT-PCR and western blotting …
CBX3 is associated with metastasis and glutathione/glycosphingolipid metabolism in colon adenocarcinoma.
Zhong X, Ni J, Jia Z, Yan H, Zhang Y, Liu Y. Zhong X, et al. J Gastrointest Oncol. 2022 Feb;13(1):246-255. doi: 10.21037/jgo-22-97. J Gastrointest Oncol. 2022. PMID: 35284119 Free PMC article.
Besides, CBX3 also exhibited a negative correlation with glycosphingolipid metabolism, which may associate with the regulation of CBX3 on DNA methylation. ...CONCLUSIONS: Our study demonstrated that CBX3 overexpression is associated with COAD metastasis. C …
Besides, CBX3 also exhibited a negative correlation with glycosphingolipid metabolism, which may associate with the regulation of …
CBX3/HP1gamma promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.
Zhong X, Kan A, Zhang W, Zhou J, Zhang H, Chen J, Tang S. Zhong X, et al. Aging (Albany NY). 2019 Aug 2;11(15):5483-5497. doi: 10.18632/aging.102132. Epub 2019 Aug 2. Aging (Albany NY). 2019. PMID: 31375643 Free PMC article.
HP1gamma, encoded by CBX3, is associated with cancer progression and patient prognosis. ...We found that CBX3/HP1gamma was upregulated in many cancers and was associated with poor prognosis. ...
HP1gamma, encoded by CBX3, is associated with cancer progression and patient prognosis. ...We found that CBX3/HP1gamma was upr …
233 results