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Front Vet Sci. 2018 Jul 23;5:165. doi: 10.3389/fvets.2018.00165. eCollection 2018.

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs.

Author information

1
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
2
Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
3
Department of Population Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
4
Proteomic and Metabolomic Facility, Colorado State University, Fort Collins, CO, United States.
5
Metzger Animal Hospital, State College, PA, United States.

Abstract

Objectives: The objectives of this study were to determine basic oral pharmacokinetics, and assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA). Methods: Single-dose pharmacokinetics was performed using two different doses of CBD enriched (2 and 8 mg/kg) oil. Thereafter, a randomized placebo-controlled, veterinarian, and owner blinded, cross-over study was conducted. Dogs received each of two treatments: CBD oil (2 mg/kg) or placebo oil every 12 h. Each treatment lasted for 4 weeks with a 2-week washout period. Baseline veterinary assessment and owner questionnaires were completed before initiating each treatment and at weeks 2 and 4. Hematology, serum chemistry and physical examinations were performed at each visit. A mixed model analysis, analyzing the change from enrollment baseline for all other time points was utilized for all variables of interest, with a p ≤ 0.05 defined as significant. Results: Pharmacokinetics revealed an elimination half-life of 4.2 h at both doses and no observable side effects. Clinically, canine brief pain inventory and Hudson activity scores showed a significant decrease in pain and increase in activity (p < 0.01) with CBD oil. Veterinary assessment showed decreased pain during CBD treatment (p < 0.02). No side effects were reported by owners, however, serum chemistry showed an increase in alkaline phosphatase during CBD treatment (p < 0.01). Clinical significance: This pharmacokinetic and clinical study suggests that 2 mg/kg of CBD twice daily can help increase comfort and activity in dogs with OA.

KEYWORDS:

CBD oil; canine; cannabidiol; hemp; osteoarthritis; pharmacokinetic

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