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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 8
1998 3
1999 6
2000 5
2001 2
2002 1
2003 1
2004 8
2005 7
2006 13
2007 9
2008 12
2009 20
2010 23
2011 21
2012 34
2013 53
2014 41
2015 50
2016 58
2017 71
2018 95
2019 128
2020 167
2021 151
2022 144
2023 131
2024 35

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1,151 results

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Page 1
CASP1 is a target for combination therapy in pancreatic cancer.
Wang X, Chen Z, Nie D, Zeng X, Zhong M, Liu X, Zhong S, Wang L, Liao Z, Chen C, Li Y, Zeng C. Wang X, et al. Eur J Pharmacol. 2023 Dec 15;961:176175. doi: 10.1016/j.ejphar.2023.176175. Epub 2023 Nov 8. Eur J Pharmacol. 2023. PMID: 37949157
Knockdown of either CASP1 or GSDMD resulted in the inhibition of cell viability and migration in PC cells. More importantly, the knockdown of CASP1 or GSDMD enhanced GEM-induced cell death in PC cells. Interestingly, subsequent investigations demonstrated that enzym …
Knockdown of either CASP1 or GSDMD resulted in the inhibition of cell viability and migration in PC cells. More importantly, the knoc …
Expression and prognosis analyses of CASP1 in acute myeloid leukemia.
Liu J, Zhao M, Feng X, Zeng Y, Lin D. Liu J, et al. Aging (Albany NY). 2021 May 17;13(10):14088-14108. doi: 10.18632/aging.203028. Epub 2021 May 17. Aging (Albany NY). 2021. PMID: 33999861 Free PMC article.
Then, we verified the mRNA expression of CASP1 in AML clinical samples and observed significantly higher expression of CASP1 in relapsed AML patients. High CASP1 expression was associated with poor prognosis and CASP1 inhibition could impair the prolif …
Then, we verified the mRNA expression of CASP1 in AML clinical samples and observed significantly higher expression of CASP1 i …
The NLRC4 Inflammasome.
Duncan JA, Canna SW. Duncan JA, et al. Immunol Rev. 2018 Jan;281(1):115-123. doi: 10.1111/imr.12607. Immunol Rev. 2018. PMID: 29247997 Free PMC article. Review.
The current understanding of the NLRC4 inflammasome is perhaps the most comprehensive illustration of the inflammasome paradigm: trigger (e.g. cytosolic flagellin), sensor (NAIP), nucleator (NLRC4), adaptor (ASC), and effector (CASP1). Detailed work has also identified obs …
The current understanding of the NLRC4 inflammasome is perhaps the most comprehensive illustration of the inflammasome paradigm: trigger (e. …
CASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor.
Zou C, Beard JA, Yang G, Evans WE, Bonten EJ. Zou C, et al. J Inflamm Res. 2022 Feb 19;15:1183-1194. doi: 10.2147/JIR.S333725. eCollection 2022. J Inflamm Res. 2022. PMID: 35221708 Free PMC article.
Next, a LV fluorescence-based biosensor (CASPorter) was transduced in the HEK293-iASC-NLRP3/CASP1 cell line to monitor the real-time activation of CASP1/NALP3 inflammasome in live cells. ...RESULTS: Dox treatment significantly induced ASC expression and increased le …
Next, a LV fluorescence-based biosensor (CASPorter) was transduced in the HEK293-iASC-NLRP3/CASP1 cell line to monitor the real-time …
Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation.
Yu X, Liu X, Liu X, Jin S, Zhong M, Nie D, Zeng X, Wang X, Tan J, Li Y, Zeng C. Yu X, et al. Eur J Pharmacol. 2023 Apr 15;945:175614. doi: 10.1016/j.ejphar.2023.175614. Epub 2023 Feb 22. Eur J Pharmacol. 2023. PMID: 36822457
Caspase-1 (CASP1)-mediated classical pyroptosis plays a key role in cancer development and management, however, the role of CASP1 and its regulation has not yet been documented for acute promyelocytic leukemia (APL). ...We showed that ATRA increases and activates …
Caspase-1 (CASP1)-mediated classical pyroptosis plays a key role in cancer development and management, however, the role of CASP1
CASP1 Gene Polymorphisms and BAT1-NFKBIL-LTA-CASP1 Gene-Gene Interactions Are Associated with Restenosis after Coronary Stenting.
Vargas-Alarcón G, Ramírez-Bello J, Peña-Duque MA, Martínez-Ríos MA, Delgadillo-Rodríguez H, Fragoso JM. Vargas-Alarcón G, et al. Biomolecules. 2022 May 31;12(6):765. doi: 10.3390/biom12060765. Biomolecules. 2022. PMID: 35740890 Free PMC article.
The allele and genotype determination of the polymorphisms (BAT1 rs2239527 C/G, NFKBIL1 rs2071592 T/A, LTA rs1800683 G/A, CASP1 rs501192 A/G, and CASP1 rs580253 A/G) were performed by 5'exonuclease TaqMan assays in 219 patients: 66 patients with restenosis and 153 w …
The allele and genotype determination of the polymorphisms (BAT1 rs2239527 C/G, NFKBIL1 rs2071592 T/A, LTA rs1800683 G/A, CASP1 rs501 …
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. Heneka MT, et al. Nature. 2013 Jan 31;493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19. Nature. 2013. PMID: 23254930 Free PMC article.
Here we demonstrate strongly enhanced active caspase-1 expression in human mild cognitive impairment and brains with Alzheimer's disease, suggesting a role for the inflammasome in this neurodegenerative disease. Nlrp3(-/-) or Casp1(-/-) mice carrying mutations associated w …
Here we demonstrate strongly enhanced active caspase-1 expression in human mild cognitive impairment and brains with Alzheimer's disease, su …
Non-canonical inflammasome activation targets caspase-11.
Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM. Kayagaki N, et al. Nature. 2011 Oct 16;479(7371):117-21. doi: 10.1038/nature10558. Nature. 2011. PMID: 22002608
This finding is important because published targeting of the Casp1 gene was done using strain 129 embryonic stem cells. Casp1 and Casp11 are too close in the genome to be segregated by recombination; consequently, the published Casp1(-/-) mice lack both caspa …
This finding is important because published targeting of the Casp1 gene was done using strain 129 embryonic stem cells. Casp1
CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability.
Kapplusch F, Schulze F, Rabe-Matschewsky S, Russ S, Herbig M, Heymann MC, Schoepf K, Stein R, Range U, Rösen-Wolff A, Winkler S, Hedrich CM, Guck J, Hofmann SR. Kapplusch F, et al. Clin Immunol. 2019 Nov;208:108232. doi: 10.1016/j.clim.2019.06.008. Epub 2019 Jun 26. Clin Immunol. 2019. PMID: 31252176
CASP1 variants result in reduced enzymatic activity of procaspase-1 and impaired IL-1beta release. ...THP1-derived macrophages carrying CASP1 variants exhibited mutation-specific molecular alterations. ...
CASP1 variants result in reduced enzymatic activity of procaspase-1 and impaired IL-1beta release. ...THP1-derived macrophages carryi
A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis.
Brandsma E, Kloosterhuis NJ, Koster M, Dekker DC, Gijbels MJJ, van der Velden S, Ríos-Morales M, van Faassen MJR, Loreti MG, de Bruin A, Fu J, Kuipers F, Bakker BM, Westerterp M, de Winther MPJ, Hofker MH, van de Sluis B, Koonen DPY. Brandsma E, et al. Circ Res. 2019 Jan 4;124(1):94-100. doi: 10.1161/CIRCRESAHA.118.313234. Circ Res. 2019. PMID: 30582442 Free PMC article.
OBJECTIVE: Here, we investigated whether a proinflammatory microbiota from Caspase1(-/-) ( Casp1(-/-)) mice accelerates atherogenesis in Ldlr(-/-) mice. METHOD AND RESULTS: We treated female Ldlr(-/-) mice with antibiotics and subsequently transplanted them with fecal micr …
OBJECTIVE: Here, we investigated whether a proinflammatory microbiota from Caspase1(-/-) ( Casp1(-/-)) mice accelerates atherogenesis …
1,151 results