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Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018.

Boulanger JM, Lindsay MP, Gubitz G, Smith EE, Stotts G, Foley N, Bhogal S, Boyle K, Braun L, Goddard T, Heran M, Kanya-Forster N, Lang E, Lavoie P, McClelland M, O'Kelly C, Pageau P, Pettersen J, Purvis H, Shamy M, Tampieri D, vanAdel B, Verbeek R, Blacquiere D, Casaubon L, Ferguson D, Hegedus Y, Jacquin GJ, Kelly M, Kamal N, Linkewich B, Lum C, Mann B, Milot G, Newcommon N, Poirier P, Simpkin W, Snieder E, Trivedi A, Whelan R, Eustace M, Smitko E, Butcher K; Acute Stroke Management Best Practice Writing Group, and the Canadian Stroke Best Practices and Quality Advisory Committees; in collaboration with the Canadian Stroke Consortium and the Canadian Association of Emergency Physicians.

Int J Stroke. 2018 Jan 1:1747493018786616. doi: 10.1177/1747493018786616. [Epub ahead of print]


Intravenous Thrombolysis May Not Improve Clinical Outcome of Acute Ischemic Stroke Patients Without a Baseline Vessel Occlusion.

Tian H, Parsons MW, Levi CR, Cheng X, Aviv RI, Spratt NJ, Kleinig TJ, O'Brien B, Butcher KS, Lin L, Zhang J, Dong Q, Chen C, Bivard A.

Front Neurol. 2018 Jun 6;9:405. doi: 10.3389/fneur.2018.00405. eCollection 2018.


Quantitative Susceptibility Mapping for Following Intracranial Hemorrhage.

Sun H, Klahr AC, Kate M, Gioia LC, Emery DJ, Butcher KS, Wilman AH.

Radiology. 2018 Jun 19:171918. doi: 10.1148/radiol.2018171918. [Epub ahead of print]


Computed Tomographic Perfusion Predicts Poor Outcomes in a Randomized Trial of Endovascular Therapy.

Wannamaker R, Guinand T, Menon BK, Demchuk A, Goyal M, Frei D, Bharatha A, Jovin TG, Shankar J, Krings T, Baxter B, Holmstedt C, Swartz R, Dowlatshahi D, Chan R, Tampieri D, Choe H, Burns P, Gentile N, Rempel J, Shuaib A, Buck B, Bivard A, Hill M, Butcher K.

Stroke. 2018 Jun;49(6):1426-1433. doi: 10.1161/STROKEAHA.117.019806. Epub 2018 May 8.


Blood pressure reduction in hypertensive acute ischemic stroke patients does not affect cerebral blood flow.

Kate M, Asdaghi N, Gioia LC, Buck B, Majumdar SR, Jeerakathil T, Shuaib A, Emery D, Beaulieu C, Butcher K.

J Cereb Blood Flow Metab. 2018 Jan 1:271678X18774708. doi: 10.1177/0271678X18774708. [Epub ahead of print]


Penumbral Imaging-Based Thrombolysis with Tenecteplase Is Feasible up to 24 Hours after Symptom Onset.

Kate M, Wannamaker R, Kamble H, Riaz P, Gioia LC, Buck B, Jeerakathil T, Smyth P, Shuaib A, Butcher K, Emery D.

J Stroke. 2018 Jan;20(1):122-130. doi: 10.5853/jos.2017.00178. Epub 2018 Jan 31.


Ischemic core thresholds change with time to reperfusion: A case control study.

Bivard A, Kleinig T, Miteff F, Butcher K, Lin L, Levi C, Parsons M.

Ann Neurol. 2017 Dec;82(6):995-1003. doi: 10.1002/ana.25109.


Influence of Penumbral Reperfusion on Clinical Outcome Depends on Baseline Ischemic Core Volume.

Chen C, Parsons MW, Clapham M, Oldmeadow C, Levi CR, Lin L, Cheng X, Lou M, Kleinig TJ, Butcher KS, Dong Q, Bivard A.

Stroke. 2017 Oct;48(10):2739-2745. doi: 10.1161/STROKEAHA.117.018587. Epub 2017 Sep 8.


Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.

Swain NA, Batchelor D, Beaudoin S, Bechle BM, Bradley PA, Brown AD, Brown B, Butcher KJ, Butt RP, Chapman ML, Denton S, Ellis D, Galan SRG, Gaulier SM, Greener BS, de Groot MJ, Glossop MS, Gurrell IK, Hannam J, Johnson MS, Lin Z, Markworth CJ, Marron BE, Millan DS, Nakagawa S, Pike A, Printzenhoff D, Rawson DJ, Ransley SJ, Reister SM, Sasaki K, Storer RI, Stupple PA, West CW.

J Med Chem. 2017 Aug 24;60(16):7029-7042. doi: 10.1021/acs.jmedchem.7b00598. Epub 2017 Aug 10.


Surgical clipping or endovascular coiling for unruptured intracranial aneurysms: a pragmatic randomised trial.

Darsaut TE, Findlay JM, Magro E, Kotowski M, Roy D, Weill A, Bojanowski MW, Chaalala C, Iancu D, Lesiuk H, Sinclair J, Scholtes F, Martin D, Chow MM, O'Kelly CJ, Wong JH, Butcher K, Fox AJ, Arthur AS, Guilbert F, Tian L, Chagnon M, Nolet S, Gevry G, Raymond J.

J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):663-668. doi: 10.1136/jnnp-2016-315433. Epub 2017 Jun 20.


Dabigatran following acute transient ischemic attack and minor stroke II (DATAS II).

Ng KH, Sharma M, Benavente O, Gioia L, Field TS, Hill MD, Coutts SB, Butcher K; DATAS-2 Investigators.

Int J Stroke. 2017 Oct;12(8):910-914. doi: 10.1177/1747493017711947. Epub 2017 Jun 6.


The intracerebral hemorrhage acutely decreasing arterial pressure trial II (ICH ADAPT II) protocol.

Gioia L, Klahr A, Kate M, Buck B, Dowlatshahi D, Jeerakathil T, Emery D, Butcher K.

BMC Neurol. 2017 May 19;17(1):100. doi: 10.1186/s12883-017-0884-4.


Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells.

Kannappan V, Butcher K, Trela M, Nicholl I, Wang W, Attridge K.

Cancer Immunol Immunother. 2017 May;66(5):637-645. doi: 10.1007/s00262-017-1970-6. Epub 2017 Feb 27.


Validating a Predictive Model of Acute Advanced Imaging Biomarkers in Ischemic Stroke.

Bivard A, Levi C, Lin L, Cheng X, Aviv R, Spratt NJ, Lou M, Kleinig T, O'Brien B, Butcher K, Zhang J, Jannes J, Dong Q, Parsons M.

Stroke. 2017 Mar;48(3):645-650. doi: 10.1161/STROKEAHA.116.015143. Epub 2017 Jan 19.


Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.

Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP Jr, Rosenblum M, Thompson RE, Awad IA; CLEAR III Investigators.

Lancet. 2017 Feb 11;389(10069):603-611. doi: 10.1016/S0140-6736(16)32410-2. Epub 2017 Jan 10.


Perfusion computed tomography in patients with stroke thrombolysis.

Kawano H, Bivard A, Lin L, Ma H, Cheng X, Aviv R, O'Brien B, Butcher K, Lou M, Zhang J, Jannes J, Dong Q, Levi CR, Parsons MW.

Brain. 2017 Mar 1;140(3):684-691. doi: 10.1093/brain/aww338.


Acute Blood Pressure Management in Intracerebral Hemorrhage: Equipoise Resists an Attack.

Butcher K, Selim M.

Stroke. 2016 Dec;47(12):3065-3066. Epub 2016 Nov 15. No abstract available.


Infarct in a New Territory After Treatment Administration in the ESCAPE Randomized Controlled Trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times).

Ganesh A, Al-Ajlan FS, Sabiq F, Assis Z, Rempel JL, Butcher K, Thornton J, Kelly P, Roy D, Poppe AY, Jovin TG, Devlin T, Baxter BW, Krings T, Casaubon LK, Frei DF, Choe H, Tampieri D, Teitelbaum J, Lum C, Mandzia J, Phillips SJ, Bang OY, Almekhlafi MA, Coutts SB, Barber PA, Sajobi T, Demchuk AM, Eesa M, Hill MD, Goyal M, Menon BK; ESCAPE Trial Investigators.

Stroke. 2016 Dec;47(12):2993-2998. Epub 2016 Nov 10.


White matter hyperintensity volume predicts persistent cognitive impairment in transient ischemic attack and minor stroke.

Sivakumar L, Riaz P, Kate M, Jeerakathil T, Beaulieu C, Buck B, Camicioli R, Butcher K.

Int J Stroke. 2017 Apr;12(3):264-272. doi: 10.1177/1747493016676612. Epub 2016 Oct 26.


Thrombolysis and thrombectomy in patients treated with dabigatran with acute ischemic stroke: Expert opinion.

Diener HC, Bernstein R, Butcher K, Campbell B, Cloud G, Davalos A, Davis S, Ferro JM, Grond M, Krieger D, Ntaios G, Slowik A, Touzé E.

Int J Stroke. 2017 Jan;12(1):9-12. doi: 10.1177/1747493016669849. Epub 2016 Sep 30.


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