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Items: 1 to 20 of 849

1.

In Vitro Exposure to Prostratin but Not Bryostatin-1 Improves Natural Killer Cell Functions Including Killing of CD4+ T Cells Harboring Reactivated Human Immunodeficiency Virus.

Desimio MG, Giuliani E, Ferraro AS, Adorno G, Doria M.

Front Immunol. 2018 Jun 29;9:1514. doi: 10.3389/fimmu.2018.01514. eCollection 2018.

2.

Inhibition of Inflammation, Suppression of Matrix Metalloproteinases, Induction of Neurogenesis, and Antioxidant Property Make Bryostatin-1 a Therapeutic Choice for Multiple Sclerosis.

Safaeinejad F, Bahrami S, Redl H, Niknejad H.

Front Pharmacol. 2018 Jun 19;9:625. doi: 10.3389/fphar.2018.00625. eCollection 2018.

3.

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.

Marsden MD, Wu X, Navab SM, Loy BA, Schrier AJ, DeChristopher BA, Shimizu AJ, Hardman CT, Ho S, Ramirez CM, Wender PA, Zack JA.

Virology. 2018 Jul;520:83-93. doi: 10.1016/j.virol.2018.05.006. Epub 2018 May 26.

4.

Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery.

Tian XR, Tang HF, Tian XL, Hu JJ, Huang LL, Gustafson KR.

Future Med Chem. 2018 Jun 1;10(12):1497-1514. doi: 10.4155/fmc-2018-0012. Epub 2018 May 23.

PMID:
29788787
5.

Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.

Slocum ST, Lowell AN, Tripathi AN, Shende VV, Smith JL, Sherman DH.

Methods Enzymol. 2018;604:207-236. doi: 10.1016/bs.mie.2018.01.034. Epub 2018 Apr 9.

PMID:
29779653
6.

Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus.

Sen A, Nelson TJ, Alkon DL, Hongpaisan J.

J Alzheimers Dis. 2018;63(3):1173-1189. doi: 10.3233/JAD-171008.

PMID:
29710707
7.

Protein kinase C activator bryostatin-1 modulates proteasome function.

Khan TK, Nelson TJ.

J Cell Biochem. 2018 Aug;119(8):6894-6904. doi: 10.1002/jcb.26887. Epub 2018 Apr 25.

PMID:
29693282
8.

Exposure to far-infrared rays attenuates methamphetamine-induced recognition memory impairment via modulation of the muscarinic M1 receptor, Nrf2, and PKC.

Mai HN, Sharma N, Shin EJ, Nguyen BT, Nguyen PT, Jeong JH, Jang CG, Cho EH, Nah SY, Kim NH, Nabeshima T, Kim HC.

Neurochem Int. 2018 Jun;116:63-76. doi: 10.1016/j.neuint.2018.03.009. Epub 2018 Mar 20.

PMID:
29572053
9.

Acute stress enhances learning and memory by activating acid-sensing ion channels in rats.

Ye S, Yang R, Xiong Q, Yang Y, Zhou L, Gong Y, Li C, Ding Z, Ye G, Xiong Z.

Biochem Biophys Res Commun. 2018 Apr 15;498(4):1078-1084. doi: 10.1016/j.bbrc.2018.03.122. Epub 2018 Mar 19.

PMID:
29555470
10.

Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues.

Yahiro K, Nagasawa S, Ichimura K, Takeuchi H, Ogura K, Tsutsuki H, Shimizu T, Iyoda S, Ohnishi M, Iwase H, Moss J, Noda M.

Cell Death Discov. 2018 Feb 14;4:22. doi: 10.1038/s41420-017-0007-4. eCollection 2018 Dec.

11.

Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and Potency.

Zhao X, Kedei N, Michalowski A, Lewin NE, Keck GE, Blumberg PM.

Chembiochem. 2018 May 18;19(10):1049-1059. doi: 10.1002/cbic.201700677. Epub 2018 Apr 27.

PMID:
29517836
12.

Bryostatin-1 alleviates experimental multiple sclerosis.

Kornberg MD, Smith MD, Shirazi HA, Calabresi PA, Snyder SH, Kim PM.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2186-2191. doi: 10.1073/pnas.1719902115. Epub 2018 Feb 12.

PMID:
29440425
13.

Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues.

Cummins TJ, Kedei N, Czikora A, Lewin NE, Kirk S, Petersen ME, McGowan KM, Chen JQ, Luo X, Johnson RC, Ravichandran S, Blumberg PM, Keck GE.

Chembiochem. 2018 Apr 16;19(8):877-889. doi: 10.1002/cbic.201700655. Epub 2018 Mar 25.

PMID:
29424951
14.

REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment.

Yang H, Staveness D, Ryckbosch SM, Axtman AD, Loy BA, Barnes AB, Pande VS, Schaefer J, Wender PA, Cegelski L.

ACS Cent Sci. 2018 Jan 24;4(1):89-96. doi: 10.1021/acscentsci.7b00475. Epub 2018 Jan 2.

15.
16.

Class 1-Selective Histone Deacetylase (HDAC) Inhibitors Enhance HIV Latency Reversal while Preserving the Activity of HDAC Isoforms Necessary for Maximal HIV Gene Expression.

Zaikos TD, Painter MM, Sebastian Kettinger NT, Terry VH, Collins KL.

J Virol. 2018 Feb 26;92(6). pii: e02110-17. doi: 10.1128/JVI.02110-17. Print 2018 Mar 15.

PMID:
29298886
17.

Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.

Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ.

J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.

18.

Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy.

Zhang Y, Guo Q, Sun X, Lu J, Cao Y, Pu Q, Chu Z, Gao L, Song Z.

Angew Chem Int Ed Engl. 2018 Jan 22;57(4):942-946. doi: 10.1002/anie.201711452. Epub 2017 Dec 20.

PMID:
29210495
19.

Bryostatin 1 causes attenuation of TPA‑mediated tumor promotion in mouse skin.

Zeng N, Xu Y, Wu Y, Hongbo T, Wu M.

Mol Med Rep. 2018 Jan;17(1):1077-1082. doi: 10.3892/mmr.2017.7993. Epub 2017 Nov 6.

PMID:
29115558
20.

Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10.

Green AP, Hardy S, Lee ATL, Thomas EJ.

Org Biomol Chem. 2017 Nov 15;15(44):9497-9526. doi: 10.1039/c7ob02129a.

PMID:
29109995

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