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J Neurosci. 2016 Mar 2;36(9):2757-68. doi: 10.1523/JNEUROSCI.2975-15.2016.

Brain Regions Influencing Implicit Violent Attitudes: A Lesion-Mapping Study.

Author information

1
Rehabilitation Institute of Chicago, Chicago, Illinois 60611, Department of Physical Medicine and Rehabilitation and jgrafman@northwestern.edu irene.cristofori@gmail.com.
2
Rehabilitation Institute of Chicago, Chicago, Illinois 60611, Department of Physical Medicine and Rehabilitation and.
3
Rehabilitation Institute of Chicago, Chicago, Illinois 60611.
4
Molecular Neuroscience Department and Department of Psychology, George Mason University, Fairfax, Virginia 22030.
5
Department of Psychology, George Mason University, Fairfax, Virginia 22030.
6
Rehabilitation Institute of Chicago, Chicago, Illinois 60611, Department of Physical Medicine and Rehabilitation and Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, and jgrafman@northwestern.edu irene.cristofori@gmail.com.

Abstract

Increased aggression is common after traumatic brain injuries and may persist after cognitive recovery. Maladaptive aggression and violence are associated with dysfunction in the prefrontal and temporal cortex, but such dysfunctional behaviors are typically measured by explicit scales and history. However, it is well known that answers on explicit scales on sensitive topics--such as aggressive thoughts and behaviors--may not reveal true tendencies. Here, we investigated the neural basis of implicit attitudes toward aggression in humans using a modified version of the Implicit Association Task (IAT) with a unique sample of 112 Vietnam War veterans who suffered penetrating brain injury and 33 healthy controls who also served in combat in Vietnam but had no history of brain injury. We hypothesized that dorsolateral prefrontal cortex (dlPFC) lesions, due to the crucial role of the dlPFC in response inhibition, could influence performance on the IAT. In addition, we investigated the causal contribution of specific brain areas to implicit attitudes toward violence. We found a more positive implicit attitude toward aggression among individuals with lesions to the dlPFC and inferior posterior temporal cortex (ipTC). Furthermore, executive functions were critically involved in regulating implicit attitudes toward violence and aggression. Our findings complement existing evidence on the neural basis of explicit aggression centered on the ventromedial prefrontal cortex. These findings highlight that dlPFC and ipTC play a causal role in modulating implicit attitudes about violence and are crucially involved in the pathogenesis of aggressive behavior.

SIGNIFICANCE STATEMENT:

Maladaptive aggression and violence can lead to interpersonal conflict and criminal behavior. Surprisingly little is known about implicit attitudes toward violence and aggression. Here, we used a range of techniques, including voxel-based lesion-symptom mapping, to examine the causal role of brain structures underpinning implicit attitudes toward aggression in a unique sample of combat veterans with traumatic brain injury. We found that damage to the dorsolateral prefrontal cortex (dlPFC) led to a more positive implicit attitude toward violence that under most normal situations would be considered inappropriate. These results suggest that treatments aimed at increasing cognitive control using cognitive behavioral therapies dependent on the intact dlPFC could treat aggressive and violent behavior.

KEYWORDS:

aggression; implicit attitudes; traumatic brain injury

PMID:
26937013
DOI:
10.1523/JNEUROSCI.2975-15.2016
[Indexed for MEDLINE]
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