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Sci Rep. 2019 Sep 19;9(1):13532. doi: 10.1038/s41598-019-49914-3.

Brain atrophy and patch-based grading in individuals from the CIMA-Q study: a progressive continuum from subjective cognitive decline to AD.

Author information

1
Centre de recherche CERVO Research Centre, Québec, Canada.
2
Montreal Neurological Institute, McGill University, Montreal, Canada.
3
True Positive Medical Devices Inc., Montreal, Canada.
4
Département de neurosciences, Université de Montréal, Montréal, Canada.
5
Centre de recherche de l'Institut universitaire de gériatrie de Montréal, Montréal, Canada.
6
Centre de recherche CERVO Research Centre, Québec, Canada. simon.duchesne@fmed.ulaval.ca.
7
True Positive Medical Devices Inc., Montreal, Canada. simon.duchesne@fmed.ulaval.ca.
8
Département de radiologie et médecine nucléaire, Faculté de médecine, Université Laval, Québec, Canada. simon.duchesne@fmed.ulaval.ca.

Abstract

It has been proposed that individuals developing Alzheimer's disease (AD) first experience a phase expressing subjective complaints of cognitive decline (SCD) without objective cognitive impairment. Using magnetic resonance imaging (MRI), our objective was to verify whether SNIPE probability grading, a new MRI analysis technique, would distinguish between clinical dementia stage of AD: Cognitively healthy controls without complaint (CH), SCD, mild cognitive impairment, and AD. SNIPE score in the hippocampus and entorhinal cortex was applied to anatomical T1-weighted MRI of 143 participants from the Consortium pour l'identification précoce de la maladie Alzheimer - Québec (CIMA-Q) study and compared to standard atrophy measures (volumes and cortical thicknesses). Compared to standard atrophy measures, SNIPE score appeared more sensitive to differentiate clinical AD since differences between groups reached a higher level of significance and larger effect sizes. However, no significant difference was observed between SCD and CH groups. Combining both types of measures did not improve between-group differences. Further studies using a combination of biomarkers beyond anatomical MRI might be needed to identify individuals with SCD who are on the beginning of the clinical continuum of AD.

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