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Items: 1 to 20 of 102

1.

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.

Hecker SJ, Reddy KR, Totrov M, Hirst GC, Lomovskaya O, Griffith DC, King P, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Clifton MC, Atkins K, Raymond A, Potts KT, Abendroth J, Boyer SH, Loutit JS, Morgan EE, Durso S, Dudley MN.

J Med Chem. 2015 May 14;58(9):3682-92. doi: 10.1021/acs.jmedchem.5b00127. Epub 2015 Mar 17.

PMID:
25782055
2.

Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.

Carroll SS, Koeplinger K, Vavrek M, Zhang NR, Handt L, MacCoss M, Olsen DB, Reddy KR, Sun Z, van Poelje PD, Fujitaki JM, Boyer SH, Linemeyer DL, Hecker SJ, Erion MD.

Antimicrob Agents Chemother. 2011 Aug;55(8):3854-60. doi: 10.1128/AAC.01152-10. Epub 2011 May 31.

3.

A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis.

Gómez-Galeno JE, Dang Q, Nguyen TH, Boyer SH, Grote MP, Sun Z, Chen M, Craigo WA, van Poelje PD, MacKenna DA, Cable EE, Rolzin PA, Finn PD, Chi B, Linemeyer DL, Hecker SJ, Erion MD.

ACS Med Chem Lett. 2010 Aug 30;1(9):478-82. doi: 10.1021/ml100143q. eCollection 2010 Dec 9.

4.

Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma.

MacKenna DA, Montag A, Boyer SH, Linemeyer DL, Erion MD.

Cancer Chemother Pharmacol. 2009 Oct;64(5):981-91. doi: 10.1007/s00280-009-0953-5. Epub 2009 Mar 13.

PMID:
19283354
5.

Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.

Boyer SH, Jiang H, Jacintho JD, Reddy MV, Li H, Li W, Godwin JL, Schulz WG, Cable EE, Hou J, Wu R, Fujitaki JM, Hecker SJ, Erion MD.

J Med Chem. 2008 Nov 27;51(22):7075-93. doi: 10.1021/jm800824d.

PMID:
18975928
6.

Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.

Reddy KR, Matelich MC, Ugarkar BG, Gómez-Galeno JE, DaRe J, Ollis K, Sun Z, Craigo W, Colby TJ, Fujitaki JM, Boyer SH, van Poelje PD, Erion MD.

J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216. Epub 2008 Jan 4.

PMID:
18173234
7.

Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.

Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, Zhang BH, Hou J, Boyer SH, van Poelje PD, Linemeyer DL.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. Epub 2007 Sep 18.

8.

Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.

Hecker SJ, Reddy KR, van Poelje PD, Sun Z, Huang W, Varkhedkar V, Reddy MV, Fujitaki JM, Olsen DB, Koeplinger KA, Boyer SH, Linemeyer DL, MacCoss M, Erion MD.

J Med Chem. 2007 Aug 9;50(16):3891-6. Epub 2007 Jul 18.

PMID:
17636948
9.

Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma.

Boyer SH, Sun Z, Jiang H, Esterbrook J, Gómez-Galeno JE, Craigo W, Reddy KR, Ugarkar BG, MacKenna DA, Erion MD.

J Med Chem. 2006 Dec 28;49(26):7711-20.

PMID:
17181153
10.

Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues.

Boyer SH, Ugarkar BG, Solbach J, Kopcho J, Matelich MC, Ollis K, Gomez-Galeno JE, Mendonca R, Tsuchiya M, Nagahisa A, Nakane M, Wiesner JB, Erion MD.

J Med Chem. 2005 Oct 6;48(20):6430-41.

PMID:
16190769
11.

Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver.

Erion MD, Reddy KR, Boyer SH, Matelich MC, Gomez-Galeno J, Lemus RH, Ugarkar BG, Colby TJ, Schanzer J, Van Poelje PD.

J Am Chem Soc. 2004 Apr 28;126(16):5154-63.

PMID:
15099098
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15.

Isolation and characterization of a rat delta-aminolevulinate dehydratase processed pseudogene.

Bishop TR, Frelin LP, Boyer SH.

Genomics. 1990 Aug;7(4):629-32.

PMID:
2387590
16.

Erythropoietin receptors on murine erythroid colony-forming units: natural history.

Landschulz KT, Noyes AN, Rogers O, Boyer SH.

Blood. 1989 May 1;73(6):1476-86.

17.

Cloning and sequence of mouse erythroid delta-aminolevulinate dehydratase cDNA.

Bishop TR, Hodes ZI, Frelin LP, Boyer SH.

Nucleic Acids Res. 1989 Feb 25;17(4):1775. No abstract available.

18.

The emerging complexity of genetic control of persistent fetal hemoglobin biosynthesis in adults.

Boyer SH.

Ann N Y Acad Sci. 1989;565:23-36. Review. No abstract available.

PMID:
2476063
20.

Patterns of differential gene expression during maturation of erythroid colony forming units.

Boyer SH, Landschulz KT, Bishop TR.

Prog Clin Biol Res. 1987;251:43-54. No abstract available.

PMID:
3432273

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