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Ann Intern Med. 1996 Nov 15;125(10):822-5.

Body cavity-based malignant lymphoma containing Kaposi sarcoma-associated herpesvirus in an HIV-negative man with previous Kaposi sarcoma.

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1
Mount Sinai School of Medicine, New York, New York, USA.

Abstract

BACKGROUND:

The role of Kaposi sarcoma-associated herpesvirus in the development of malignant lymphomas in patients negative for the human immunodeficiency virus (HIV) has not been established.

OBJECTIVE:

To examine the possible role of Kaposi sarcoma-associated herpesvirus in a case of body cavity-based malignant lymphoma that occurred in an HIV-negative patient who had previously had Kaposi sarcoma.

DESIGN:

Case study.

SETTING:

Academic medical center.

PATIENT:

A 94-year-old man with lymphomatous ascites.

MEASUREMENTS:

Polymerase chain reaction (PCR) and Southern blot DNA analysis.

RESULTS:

The body cavity-based lymphoma cells were positive for Kaposi sarcoma-associated herpesvirus by PCR and were negative for other herpesviruses, including Epstein-Barr virus, cytomegalovirus, and human herpesviruses 6 and 7. Southern blot analysis of lymphoma DNA showed high levels of Kaposi sarcoma-associated herpesvirus (> 40 to 80 genomes/cell). Clonal rearrangement of the immunoglobulin JH and JK genes was present, confirming the presence of a clonal B-cell proliferation.

CONCLUSIONS:

Kaposi sarcoma-associated herpesvirus may be involved in the development of malignant lymphoma after Kaposi sarcoma in HIV-negative patients. This type of lymphoma, in contrast to body cavity-based lymphoma related to the acquired immunodeficiency syndrome, may have an indolent clinical course.

PMID:
8928989
[Indexed for MEDLINE]

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