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J Orthop Res. 2016 Apr;34(4):574-80. doi: 10.1002/jor.23050. Epub 2015 Sep 22.

Biological reaction to polyethylene particles in a murine calvarial model is highly influenced by age.

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Harris Orthopaedic Laboratory, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 1231, Boston, Massachusetts, 02114.
Laboratoire de Bioingénierie et Biomécanique Ostéo-articulaires, UMR CNRS 7052, Faculté de Médecine Paris 7-Denis Diderot, 10, Avenue de Verdun, 75010, Paris, France.


Particle-induced osteolysis is driven by multiple factors including bone metabolism, inflammation, and age. The objective of this study was to determine the influence of age on polyethylene (PE) particle-induced osteolysis in a murine calvarial model comparing 2-month-old (young) versus 24-month-old (old) mice. After PE particle implantation, calvaria were assessed at days (D) 3, D7, D14, and D21 via chemoluminescent imaging for inflammation (L-012 probe). In addition micro-computed tomography (micro-CT) and histomorphometry end points addressed the bone reaction. Inflammation peaked at D7 in young mice and D14 in old mice. Using micro-CT, a nadir of mature bone was recorded at D7 for young mice, versus D21 for old mice. Besides, regenerating bone peaked at distinct timepoints: D7 for young mice versus D21 for old mice. In the young mice group, the histomorphometric findings correlated with micro-CT regenerating bone findings at D7, associated with ample osteoïd deposition. No osteoïd could be histologically quantified in the old mice group at D7. This study demonstrated that the biological reaction to polyethylene particles is highly influenced by age.


aging; bone histomorphometry; bone micro-CT; luminescence; orthopaedic implants

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