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Items: 1 to 20 of 33

1.

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.

Villa E, Ali ES, Sahu U, Ben-Sahra I.

Cancers (Basel). 2019 May 17;11(5). pii: E688. doi: 10.3390/cancers11050688. Review.

2.

PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness.

Kaminski L, Torrino S, Dufies M, Djabari Z, Haider R, Roustan FR, Jaune E, Laurent K, Nottet N, Michiels JF, Gesson M, Rocchi S, Mazure NM, Durand M, Tanti JF, Ambrosetti D, Clavel S, Ben-Sahra I, Bost F.

Cancer Res. 2019 Jul 1;79(13):3268-3280. doi: 10.1158/0008-5472.CAN-18-2043. Epub 2019 May 7.

PMID:
31064849
3.

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase.

Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD.

Science. 2019 Mar 8;363(6431):1088-1092. doi: 10.1126/science.aau3903.

PMID:
30846598
4.

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS.

Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM.

Nat Protoc. 2019 Feb;14(2):313-330. doi: 10.1038/s41596-018-0102-x.

PMID:
30683937
5.

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.

Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB.

Cell Metab. 2019 Feb 5;29(2):443-456.e5. doi: 10.1016/j.cmet.2018.12.004. Epub 2018 Dec 27.

PMID:
30595481
6.

HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth.

Ben-Sahra I, Puissant A.

Cell Metab. 2018 Dec 4;28(6):805-807. doi: 10.1016/j.cmet.2018.11.009.

PMID:
30517893
7.

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function.

Sato T, Chang HC, Bayeva M, Shapiro JS, Ramos-Alonso L, Kouzu H, Jiang X, Liu T, Yar S, Sawicki KT, Chen C, Martínez-Pastor MT, Stumpo DJ, Schumacker PT, Blackshear PJ, Ben-Sahra I, Puig S, Ardehali H.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6291-E6300. doi: 10.1073/pnas.1804701115. Epub 2018 Jun 18.

8.

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.

Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR.

Cell. 2018 Mar 22;173(1):117-129.e14. doi: 10.1016/j.cell.2018.03.001.

9.

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD.

Cell Rep. 2017 Oct 31;21(5):1331-1346. doi: 10.1016/j.celrep.2017.10.029.

10.

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.

Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, Henske EP.

Oncotarget. 2017 Aug 4;8(39):64714-64727. doi: 10.18632/oncotarget.19947. eCollection 2017 Sep 12.

11.

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

Loubiere C, Clavel S, Gilleron J, Harisseh R, Fauconnier J, Ben-Sahra I, Kaminski L, Laurent K, Herkenne S, Lacas-Gervais S, Ambrosetti D, Alcor D, Rocchi S, Cormont M, Michiels JF, Mari B, Mazure NM, Scorrano L, Lacampagne A, Gharib A, Tanti JF, Bost F.

Sci Rep. 2017 Jul 11;7(1):5040. doi: 10.1038/s41598-017-05052-2.

12.

mTORC1 signaling and the metabolic control of cell growth.

Ben-Sahra I, Manning BD.

Curr Opin Cell Biol. 2017 Apr;45:72-82. doi: 10.1016/j.ceb.2017.02.012. Epub 2017 Apr 12. Review.

13.

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.

Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, Zhang Y, Perkins AS, Shannon K, Hemann MT, Puissant A, Stegmaier K.

Nat Med. 2017 Mar;23(3):301-313. doi: 10.1038/nm.4283. Epub 2017 Feb 13.

14.

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD.

Science. 2016 Feb 12;351(6274):728-733. doi: 10.1126/science.aad0489.

15.

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.

Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, Horng T.

Elife. 2016 Feb 19;5. pii: e11612. doi: 10.7554/eLife.11612.

16.

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.

Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD.

Oncogene. 2016 Mar 10;35(10):1250-60. doi: 10.1038/onc.2015.179. Epub 2015 Jun 1.

17.

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis.

Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM.

Genes Dev. 2014 Sep 1;28(17):1917-28. doi: 10.1101/gad.245910.114.

18.

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.

Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM.

Cell Death Differ. 2014 May;21(5):836-44. doi: 10.1038/cdd.2014.24. Epub 2014 Feb 28.

19.

Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia.

Rosilio C, Ben-Sahra I, Bost F, Peyron JF.

Cancer Lett. 2014 May 1;346(2):188-96. doi: 10.1016/j.canlet.2014.01.006. Epub 2014 Jan 22. Review.

PMID:
24462823
20.

The TSC-mTOR pathway regulates macrophage polarization.

Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T.

Nat Commun. 2013;4:2834. doi: 10.1038/ncomms3834.

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