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Items: 1 to 20 of 89


Structure of an Engineered Intein Reveals Thiazoline Ring and Provides Mechanistic Insight.

Pearson CS, Nemati R, Liu B, Zhang J, Scalabrin M, Li Z, Li H, Fabris D, Belfort M, Belfort G.

Biotechnol Bioeng. 2018 Nov 18. doi: 10.1002/bit.26875. [Epub ahead of print]


Mycobacterial DnaB helicase intein as oxidative stress sensor.

Kelley DS, Lennon CW, Li Z, Miller MR, Banavali NK, Li H, Belfort M.

Nat Commun. 2018 Oct 19;9(1):4363. doi: 10.1038/s41467-018-06554-x.


Meeting report: mobile genetic elements and genome plasticity 2018.

Abrams JM, Arkhipova IR, Belfort M, Boeke JD, Joan Curcio M, Faulkner GJ, Goodier JL, Lehmann R, Levin HL.

Mob DNA. 2018 Jun 22;9:21. doi: 10.1186/s13100-018-0126-3. eCollection 2018.


Group II intron inhibits conjugative relaxase expression in bacteria by mRNA targeting.

Qu G, Piazza CL, Smith D, Belfort M.

Elife. 2018 Jun 15;7. pii: e34268. doi: 10.7554/eLife.34268.


Structural accommodations accompanying splicing of a group II intron RNP.

Dong X, Ranganathan S, Qu G, Piazza CL, Belfort M.

Nucleic Acids Res. 2018 Sep 19;46(16):8542-8556. doi: 10.1093/nar/gky416.


The dynamic intein landscape of eukaryotes.

Green CM, Novikova O, Belfort M.

Mob DNA. 2018 Jan 24;9:4. doi: 10.1186/s13100-018-0111-x. eCollection 2018.


Conditional Protein Splicing Switch in Hyperthermophiles through an Intein-Extein Partnership.

Lennon CW, Stanger M, Banavali NK, Belfort M.

MBio. 2018 Jan 30;9(1). pii: e02304-17. doi: 10.1128/mBio.02304-17.


Mobile Group II Introns as Ancestral Eukaryotic Elements.

Novikova O, Belfort M.

Trends Genet. 2017 Nov;33(11):773-783. doi: 10.1016/j.tig.2017.07.009. Epub 2017 Aug 14. Review.


Mobile self-splicing introns and inteins as environmental sensors.

Belfort M.

Curr Opin Microbiol. 2017 Aug;38:51-58. doi: 10.1016/j.mib.2017.04.003. Epub 2017 May 5. Review.



Lennon CW, Belfort M.

Curr Biol. 2017 Mar 20;27(6):R204-R206. doi: 10.1016/j.cub.2017.01.016.


Protein splicing of a recombinase intein induced by ssDNA and DNA damage.

Lennon CW, Stanger M, Belfort M.

Genes Dev. 2016 Dec 15;30(24):2663-2668. doi: 10.1101/gad.289280.116. Epub 2016 Dec 28.


Forks in the tracks: Group II introns, spliceosomes, telomeres and beyond.

Agrawal RK, Wang HW, Belfort M.

RNA Biol. 2016 Dec;13(12):1218-1222. Epub 2016 Oct 11.


Mycobacteriophages as Incubators for Intein Dissemination and Evolution.

Kelley DS, Lennon CW; SEA-PHAGES, Belfort M, Novikova O.

MBio. 2016 Oct 4;7(5). pii: e01537-16. doi: 10.1128/mBio.01537-16.


Exploring Intein Inhibition by Platinum Compounds as an Antimicrobial Strategy.

Chan H, Pearson CS, Green CM, Li Z, Zhang J, Belfort G, Shekhtman A, Li H, Belfort M.

J Biol Chem. 2016 Oct 21;291(43):22661-22670. Epub 2016 Sep 8.


Structure of a group II intron in complex with its reverse transcriptase.

Qu G, Kaushal PS, Wang J, Shigematsu H, Piazza CL, Agrawal RK, Belfort M, Wang HW.

Nat Struct Mol Biol. 2016 Jun;23(6):549-57. doi: 10.1038/nsmb.3220. Epub 2016 May 2.


Intein Clustering Suggests Functional Importance in Different Domains of Life.

Novikova O, Jayachandran P, Kelley DS, Morton Z, Merwin S, Topilina NI, Belfort M.

Mol Biol Evol. 2016 Mar;33(3):783-99. doi: 10.1093/molbev/msv271. Epub 2015 Nov 25.


SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses.

Topilina NI, Green CM, Jayachandran P, Kelley DS, Stanger MJ, Piazza CL, Nayak S, Belfort M.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10348-53. doi: 10.1073/pnas.1512777112. Epub 2015 Aug 3.


Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution.

Lambowitz AM, Belfort M.

Microbiol Spectr. 2015 Feb;3(1):MDNA3-0050-2014. doi: 10.1128/microbiolspec.MDNA3-0050-2014. Review.


Post-translational environmental switch of RadA activity by extein-intein interactions in protein splicing.

Topilina NI, Novikova O, Stanger M, Banavali NK, Belfort M.

Nucleic Acids Res. 2015 Jul 27;43(13):6631-48. doi: 10.1093/nar/gkv612. Epub 2015 Jun 22.


Förster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor.

Owen TS, Ngoje G, Lageman TJ, Bordeau BM, Belfort M, Callahan BP.

Anal Biochem. 2015 Nov 1;488:1-5. doi: 10.1016/j.ab.2015.06.021. Epub 2015 Jun 18.

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