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Items: 1 to 20 of 51

1.

Screening and Identification of Cardioprotective Compounds From Wenxin Keli by Activity Index Approach and in vivo Zebrafish Model.

Liu H, Chen X, Zhao X, Zhao B, Qian K, Shi Y, Baruscotti M, Wang Y.

Front Pharmacol. 2018 Nov 13;9:1288. doi: 10.3389/fphar.2018.01288. eCollection 2018.

2.

A Loss-of-Function HCN4 Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability.

Campostrini G, DiFrancesco JC, Castellotti B, Milanesi R, Gnecchi-Ruscone T, Bonzanni M, Bucchi A, Baruscotti M, Ferrarese C, Franceschetti S, Canafoglia L, Ragona F, Freri E, Labate A, Gambardella A, Costa C, Gellera C, Granata T, Barbuti A, DiFrancesco D.

Front Mol Neurosci. 2018 Aug 6;11:269. doi: 10.3389/fnmol.2018.00269. eCollection 2018.

3.

A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability.

Bonzanni M, DiFrancesco JC, Milanesi R, Campostrini G, Castellotti B, Bucchi A, Baruscotti M, Ferrarese C, Franceschetti S, Canafoglia L, Ragona F, Freri E, Labate A, Gambardella A, Costa C, Rivolta I, Gellera C, Granata T, Barbuti A, DiFrancesco D.

Neurobiol Dis. 2018 Oct;118:55-63. doi: 10.1016/j.nbd.2018.06.012. Epub 2018 Jun 21.

4.

Mammalian γ2 AMPK regulates intrinsic heart rate.

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H.

Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5.

5.

The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.

Campostrini G, Bonzanni M, Lissoni A, Bazzini C, Milanesi R, Vezzoli E, Francolini M, Baruscotti M, Bucchi A, Rivolta I, Fantini M, Severi S, Cappato R, Crotti L, J Schwartz P, DiFrancesco D, Barbuti A.

Cardiovasc Res. 2017 Aug 1;113(10):1256-1265. doi: 10.1093/cvr/cvx122.

6.

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.

Baruscotti M, Bucchi A, Milanesi R, Paina M, Barbuti A, Gnecchi-Ruscone T, Bianco E, Vitali-Serdoz L, Cappato R, DiFrancesco D.

Eur Heart J. 2017 Jan 21;38(4):280-288. doi: 10.1093/eurheartj/ehv582. No abstract available.

PMID:
28182231
7.

INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model.

Benedetti L, Ghilardi A, Rottoli E, De Maglie M, Prosperi L, Perego C, Baruscotti M, Bucchi A, Del Giacco L, Francolini M.

Sci Rep. 2016 Apr 15;6:24515. doi: 10.1038/srep24515.

8.

Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If "funny" current.

Baruscotti M, Bianco E, Bucchi A, DiFrancesco D.

J Interv Card Electrophysiol. 2016 Jun;46(1):19-28. doi: 10.1007/s10840-015-0097-y. Epub 2016 Jan 18. Review.

PMID:
26781742
9.

Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking.

Ravagli E, Bucchi A, Bartolucci C, Paina M, Baruscotti M, DiFrancesco D, Severi S.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):50-66. doi: 10.1016/j.pbiomolbio.2015.12.004. Epub 2015 Dec 21.

PMID:
26718599
10.

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction.

Milanesi R, Bucchi A, Baruscotti M.

J Interv Card Electrophysiol. 2015 Aug;43(2):121-34. doi: 10.1007/s10840-015-9998-z. Epub 2015 Apr 12. Review.

11.

Coexistence of seizure episodes and symptomatic sinoatrial arrest occurring in two sisters suggests an underlying cardioneuronal channelopathy.

Carboni GP, DiFrancesco JC, Milanesi R, Baruscotti M.

BMJ Case Rep. 2013 Sep 6;2013. pii: bcr2013200577. doi: 10.1136/bcr-2013-200577. No abstract available.

12.

Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells.

Scavone A, Capilupo D, Mazzocchi N, Crespi A, Zoia S, Campostrini G, Bucchi A, Milanesi R, Baruscotti M, Benedetti S, Antonini S, Messina G, DiFrancesco D, Barbuti A.

Circ Res. 2013 Aug 2;113(4):389-98. doi: 10.1161/CIRCRESAHA.113.301283. Epub 2013 Jun 10.

PMID:
23753573
13.

Identification of the molecular site of ivabradine binding to HCN4 channels.

Bucchi A, Baruscotti M, Nardini M, Barbuti A, Micheloni S, Bolognesi M, DiFrancesco D.

PLoS One. 2013;8(1):e53132. doi: 10.1371/journal.pone.0053132. Epub 2013 Jan 4.

14.

Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation.

Cappato R, Castelvecchio S, Ricci C, Bianco E, Vitali-Serdoz L, Gnecchi-Ruscone T, Pittalis M, De Ambroggi L, Baruscotti M, Gaeta M, Furlanello F, Di Francesco D, Lupo PP.

J Am Coll Cardiol. 2012 Oct 9;60(15):1323-9. doi: 10.1016/j.jacc.2012.06.031. Epub 2012 Sep 12.

15.

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models.

Bucchi A, Barbuti A, Difrancesco D, Baruscotti M.

Front Physiol. 2012 Jul 2;3:240. doi: 10.3389/fphys.2012.00240. eCollection 2012.

16.

A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins.

Barbuti A, Scavone A, Mazzocchi N, Terragni B, Baruscotti M, Difrancesco D.

J Mol Cell Cardiol. 2012 Aug;53(2):187-95. doi: 10.1016/j.yjmcc.2012.05.013. Epub 2012 May 31.

PMID:
22659290
17.

Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.

DiFrancesco JC, Barbuti A, Milanesi R, Coco S, Bucchi A, Bottelli G, Ferrarese C, Franceschetti S, Terragni B, Baruscotti M, DiFrancesco D.

J Neurosci. 2011 Nov 30;31(48):17327-37. doi: 10.1523/JNEUROSCI.3727-11.2011.

18.

Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process.

Avitabile D, Crespi A, Brioschi C, Parente V, Toietta G, Devanna P, Baruscotti M, Truffa S, Scavone A, Rusconi F, Biondi A, D'Alessandra Y, Vigna E, Difrancesco D, Pesce M, Capogrossi MC, Barbuti A.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1875-84. doi: 10.1152/ajpheart.00523.2010. Epub 2011 Feb 25.

19.

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.

Baruscotti M, Bucchi A, Viscomi C, Mandelli G, Consalez G, Gnecchi-Rusconi T, Montano N, Casali KR, Micheloni S, Barbuti A, DiFrancesco D.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1705-10. doi: 10.1073/pnas.1010122108. Epub 2011 Jan 10.

20.

Multinucleated giant cells with an osteoclast phenotype derived from caprine peripheral blood mononuclear cells.

Pisoni G, D'Amelio P, Sassi F, Manarolla G, Scaccabarozzi L, Locatelli C, Mazzocchi N, Baruscotti M, DiFrancesco D, Moroni P.

Vet J. 2011 Sep;189(3):361-3. doi: 10.1016/j.tvjl.2010.07.016. Epub 2010 Sep 6.

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