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Clin Rev Allergy Immunol. 2016 Jun;50(3):301-11. doi: 10.1007/s12016-015-8494-7.

Epigenetic Control of B Cell Development and B-Cell-Related Immune Disorders.

Bao Y1,2, Cao X3.

Author information

1
Center for Translational Medicine, Changzheng Hospital, Second Military Medical University, Shanghai, China. baoy_smmu@163.com.
2
National Key Laboratory of Molecular Medical Biology & Department of Immunology, Chinese Academy of Medical Sciences, Beijing, China. baoy_smmu@163.com.
3
National Key Laboratory of Molecular Medical Biology & Department of Immunology, Chinese Academy of Medical Sciences, Beijing, China. caoxt@immunol.org.

Abstract

B lymphocytes are generally recognized as the essential component of humoral immunity and also a regulator of innate immunity. The development of B cells is precisely regulated by a variety of factors via different mechanisms, including cytokine/cytokine receptors, signal transduction molecules, and transcription factors. Recent findings suggest that epigenetic factors, such as DNA methylation, histone modification, and non-coding RNA, play critical roles in establishing B cell lineage-specific gene expression profiles to define and sustain B cell identity and function. Epigenetic modifications are also sensitive to external stimuli and might bridge genetic and environmental factors in the pathogenesis or control of B-cell-related immune disorders, such as autoimmune diseases, lymphoma, and leukemia. Better understanding of the epigenetic mechanisms for regulating B cell development and involving B cell abnormal differentiation and function will shed light on the design of new therapeutic approaches to B-cell-related diseases, and potential candidates of epigenetic modulators may be identified to target epigenetic pathways to prevent or treat B cell disorders. We summarize the relevance of epigenetic marks and landscapes in the stages of B cell development, discuss the interaction of the transcriptional networks and epigenetic changes, and review the involvement of epigenetic risk in the pathogenesis of B-cell-related diseases. Understanding how specific epigenetic alterations contribute to the development of B-cell-related autoimmunity and malignancies is instrumental to control B cell disorders.

KEYWORDS:

Autoimmune disease; B cell; B cell malignancies; Development; Differentiation; Epigenetic regulation

PMID:
26066671
DOI:
10.1007/s12016-015-8494-7
[Indexed for MEDLINE]

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