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Learn Mem. 2019 Aug 15;26(9):299-306. doi: 10.1101/lm.048785.118. Print 2019 Sep.

Balanced actions of protein synthesis and degradation in memory formation.

Author information

1
Department of Structure and Function of Neural Network, Korea Brain Research Institute (KBRI), Daegu 41062, South Korea.
2
Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, South Korea.
3
School of Biological Sciences, Seoul National University, Seoul 08826, South Korea.

Abstract

Storage of long-term memory requires not only protein synthesis but also protein degradation. In this article, we overview recent publications related to this issue, stressing that the balanced actions of protein synthesis and degradation are critical for long-term memory formation. We particularly focused on the brain-derived neurotrophic factor signaling that leads to protein synthesis; proteasome- and autophagy-dependent protein degradation that removes molecular constraints; the role of Fragile X mental retardation protein in translational suppression; and epigenetic modifications that control gene expression at the genomic level. Numerous studies suggest that an imbalance between protein synthesis and degradation leads to intellectual impairment and cognitive disorders.

PMID:
31416903
PMCID:
PMC6699412
[Available on 2020-09-01]
DOI:
10.1101/lm.048785.118

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