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Curr Opin Cell Biol. 2018 Feb;50:72-78. doi: 10.1016/j.ceb.2018.01.008. Epub 2018 Feb 21.

Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides.

Author information

1
Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667, Singapore.
2
Department of Cell Biology and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3
Department of Cell Biology and Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: jctinoue@jhmi.edu.

Abstract

The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings which have deepened our understanding of the unique yet dynamic phosphoinositide profile found in the primary cilia.

PMID:
29477020
PMCID:
PMC5911401
DOI:
10.1016/j.ceb.2018.01.008
[Indexed for MEDLINE]
Free PMC Article

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