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Items: 1 to 20 of 29


Tuberous sclerosis complex exhibits a new renal cystogenic mechanism.

Bissler JJ, Zadjali F, Bridges D, Astrinidis A, Barone S, Yao Y, Redd JR, Siroky BJ, Wang Y, Finley JT, Rusiniak ME, Baumann H, Zahedi K, Gross KW, Soleimani M.

Physiol Rep. 2019 Jan;7(2):e13983. doi: 10.14814/phy2.13983.


Mutational analysis of TSC1 and TSC2 genes in Tuberous Sclerosis Complex patients from Greece.

Avgeris S, Fostira F, Vagena A, Ninios Y, Delimitsou A, Vodicka R, Vrtel R, Youroukos S, Stravopodis DJ, Vlassi M, Astrinidis A, Yannoukakos D, Voutsinas GE.

Sci Rep. 2017 Dec 1;7(1):16697. doi: 10.1038/s41598-017-16988-w.


The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1.

Markiewski MM, Vadrevu SK, Sharma SK, Chintala NK, Ghouse S, Cho JH, Fairlie DP, Paterson Y, Astrinidis A, Karbowniczek M.

J Immunol. 2017 Apr 1;198(7):2989-2999. doi: 10.4049/jimmunol.1602057. Epub 2017 Feb 22.


Quantifying autophagosomes and autolysosomes in cells using imaging flow cytometry.

Rajan R, Karbowniczek M, Pugsley HR, Sabnani MK, Astrinidis A, La-Beck NM.

Cytometry A. 2015 May;87(5):451-8. doi: 10.1002/cyto.a.22652. Epub 2015 Feb 27.


TACC3-TSC2 maintains nuclear envelope structure and controls cell division.

Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain PO, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, Pujana MA.

Cell Cycle. 2010 Mar 15;9(6):1143-55. Epub 2010 Mar 15.


The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.

Matthew EM, Hart LS, Astrinidis A, Navaraj A, Dolloff NG, Dicker DT, Henske EP, El-Deiry WS.

Cell Cycle. 2009 Dec 15;8(24):4168-75.


The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin/raptor complex.

Astrinidis A, Kim J, Kelly CM, Olofsson BA, Torabi B, Sorokina EM, Azizkhan-Clifford J.

Genes Chromosomes Cancer. 2010 Mar;49(3):282-97. doi: 10.1002/gcc.20739.


Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells.

Yu JJ, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer LF, Nicolas E, Hensley H, Jordan VC, Walker CL, Henske EP.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2635-40. doi: 10.1073/pnas.0810790106. Epub 2009 Feb 6.


Mutation detection in tumor suppressor genes using archival tissue specimens.

Astrinidis A, Henske EP.

Methods Mol Med. 2006;126:185-96.


Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.

Robb VA, Astrinidis A, Henske EP.

Mod Pathol. 2006 Jun;19(6):839-46. Erratum in: Mod Pathol. 2006 Jun;19(6):889.


Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner.

Astrinidis A, Senapedis W, Henske EP.

Hum Mol Genet. 2006 Jan 15;15(2):287-97. Epub 2005 Dec 8.


Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.

Astrinidis A, Henske EP.

Oncogene. 2005 Nov 14;24(50):7475-81. Review.


Aberrant cellular differentiation and migration in renal and pulmonary tuberous sclerosis complex.

Astrinidis A, Henske EP.

J Child Neurol. 2004 Sep;19(9):710-5. Review.


Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.


Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.

Astrinidis A, Senapedis W, Coleman TR, Henske EP.

J Biol Chem. 2003 Dec 19;278(51):51372-9. Epub 2003 Oct 9.


Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways.

Yu J, Astrinidis A, Howard S, Henske EP.

Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L694-700. Epub 2003 Aug 15.


Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration.

Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, Henske EP.

Oncogene. 2002 Dec 5;21(55):8470-6.


Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism.

Karbowniczek M, Astrinidis A, Balsara BR, Testa JR, Lium JH, Colby TV, McCormack FX, Henske EP.

Am J Respir Crit Care Med. 2003 Apr 1;167(7):976-82. Epub 2002 Oct 31.


Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells.

Khare L, Astrinidis A, Senapedis W, Adams PD, Henske EP.

J Med Genet. 2002 Sep;39(9):676-80. No abstract available.

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