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Clin Nutr. 2019 Oct;38(5):2195-2201. doi: 10.1016/j.clnu.2018.09.018. Epub 2018 Sep 26.

Association of erythrocyte n-3 polyunsaturated fatty acids with incident type 2 diabetes in a Chinese population.

Author information

1
Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, 310024, People's Republic of China. Electronic address: zhengjusheng@westlake.edu.cn.
2
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
3
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China; Department of Epidemiology, School of Basic Medical Sciences, Jinan University, Guangzhou, 510632, People's Republic of China.
4
Institute of Nutrition and Health, Qingdao University, Qingdao, 266071, People's Republic of China.
5
Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN, 46032, USA.
6
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. Electronic address: chenyum@mail.sysu.edu.cn.

Abstract

BACKGROUND & AIMS:

The association between circulating n-3 polyunsaturated fatty acid (PUFA) biomarkers and incident type 2 diabetes in Asian populations remains unclear. We aimed to examine the association of erythrocyte n-3 PUFA with incident type 2 diabetes in a Chinese population.

METHODS:

A total of 2671 participants, aged 40-75 y, free of type 2 diabetes at baseline, were included in the present analysis. Incident type 2 diabetes cases (n = 213) were ascertained during median follow-up of 5.6 years. Baseline erythrocyte fatty acids were measured by gas chromatography. We used multivariable Cox regression models to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of type 2 diabetes across quartiles of erythrocyte n-3 PUFA.

RESULTS:

After adjustment for potential confounders, HRs (95% CIs) of type 2 diabetes were 0.68 (0.47, 1.00), 0.77 (0.52, 1.15), and 0.63 (0.41, 0.95) in quartiles 2-4 of docosapentaenoic acid (C22:5n-3) (P-trend = 0.07), compared with quartile 1; and 1.08 (0.74, 1.60), 1.03 (0.70, 1.51), and 0.57 (0.38, 0.86) for eicosapentaenoic acid (C20:5n-3) (P-trend = 0.007). No association was found for docosahexaenoic acid (C22:6n-3) or alpha-linolenic acid (C18:3n-3).

CONCLUSIONS:

Erythrocyte n-3 PUFA from marine sources (C22:5n-3 and C20:5n-3), as biomarkers of dietary marine n-3 PUFA, were inversely associated with incident type 2 diabetes in this Chinese population. Future prospective investigations in other Asian populations are necessary to confirm our findings.

KEYWORDS:

Cohort study; Erythrocyte; Fatty acids; Prospective association; Type 2 diabetes

PMID:
30309708
DOI:
10.1016/j.clnu.2018.09.018
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