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Fitoterapia. 2018 Mar;125:199-207. doi: 10.1016/j.fitote.2017.11.019. Epub 2017 Nov 21.

Arundinosides A-G, new glucosyloxybenzyl 2R-benzylmalate derivatives from the aerial parts of Arundina graminifolia.

Author information

1
Strasbourg University, Faculty of Pharmacy, UMR 7200, 67400 Illkirch-Graffenstaden, France. Electronic address: florence.auberon@gmail.com.
2
Faculty of Thai Traditional Medicine, Prince of Songkla University, Hat Yai 90112, Thailand.
3
Bordeaux University, Faculty of Pharmacy, ISVV, EA 4577, USC 1366 INRA, 33400 Villenave d'Ornon Cedex, France.
4
Aix-Marseille University, Spectropôle, FR1739, Campus de St Jérôme-Service 511, 13397 Marseille, France.
5
Strasbourg University, Faculty of Pharmacy, UMR 7200, 67400 Illkirch-Graffenstaden, France; New-Caledonia University, Institut des Sciences Exactes et Appliquées (EA 7484), BP R4, 98851 Noumea Cedex, New Caledonia.
6
LVMH Recherche, 45800 Saint Jean de Braye, France.
7
Strasbourg University, Faculty of Pharmacy, UMR 7200, 67400 Illkirch-Graffenstaden, France.

Abstract

Seven new glucosyloxybenzyl 2R-benzylmalate derivatives, arundinosides A-G (1-7) were isolated from the aerial parts of the bamboo orchid Arundina graminifolia. This is the first occurrence of this class of compounds in the genus Arundina. Their planar structures and absolute configuration were determined by extensive NMR spectroscopic data as well as chemical conversion. Their neuroprotective properties were also evaluated on their potential ability to reduce the beta amyloid damage on PC12 cell model.

KEYWORDS:

Arundina graminifolia; Arundinosides; Glucosyloxybenzyl 2R-benzylmalate derivatives; Orchidaceae

PMID:
29170123
DOI:
10.1016/j.fitote.2017.11.019
[Indexed for MEDLINE]

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