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Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):695-699. doi: 10.1002/ajmg.b.31026.

Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?

Author information

1
Department of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
2
Department of Child and Adolescent Psychiatry, University Medical Centre, Utrecht, The Netherlands.
3
Rintveld Centre for Eating Disorders, Altrecht Mental Health Institute, Zeist, The Netherlands.
4
Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
5
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
6
Complex Genetics Section, Department of Medical Genetics-DBG, University Medical Center Utrecht, Utrecht, The Netherlands.

Abstract

The influence of body mass index (BMI) on susceptibility to anorexia nervosa (AN) is not clear. Recently published genome-wide association (GWA) studies of the general population identified several variants influencing BMI. We genotyped these variants in an AN sample to test for association and to investigate a combined effect of BMI-increasing alleles (as determined in the original GWA studies) on the risk of developing the disease. Individual single nucleotide polymorphisms (SNPs) were tested for association with AN in a sample of 267 AN patients and 1,636 population controls. A logistic regression for the combined effect of BMI-increasing alleles included 225 cases and 1,351 controls. We found no significant association between individual SNPs and AN. The analysis of a combined effect of BMI-increasing alleles showed absence of association with the investigated condition. The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN.

PMID:
19746409
DOI:
10.1002/ajmg.b.31026
[Indexed for MEDLINE]

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