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Funct Integr Genomics. 2009 Nov;9(4):433-46. doi: 10.1007/s10142-009-0132-0. Epub 2009 Jul 25.

Arabidopsis thaliana J-class heat shock proteins: cellular stress sensors.

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1
Biochemistry Department, Indian Institute of Science, Bangalore, India.

Abstract

Plants are sessile organisms that have evolved a variety of mechanisms to maintain their cellular homeostasis under stressful environmental conditions. Survival of plants under abiotic stress conditions requires specialized group of heat shock protein machinery, belonging to Hsp70:J-protein family. These heat shock proteins are most ubiquitous types of chaperone machineries involved in diverse cellular processes including protein folding, translocation across cell membranes, and protein degradation. They play a crucial role in maintaining the protein homeostasis by reestablishing functional native conformations under environmental stress conditions, thus providing protection to the cell. J-proteins are co-chaperones of Hsp70 machine, which play a critical role by stimulating Hsp70s ATPase activity, thereby stabilizing its interaction with client proteins. Using genome-wide analysis of Arabidopsis thaliana, here we have outlined identification and systematic classification of J-protein co-chaperones which are key regulators of Hsp70s function. In comparison with Saccharomyces cerevisiae model system, a comprehensive domain structural organization, cellular localization, and functional diversity of A. thaliana J-proteins have also been summarized.

PMID:
19633874
DOI:
10.1007/s10142-009-0132-0
[Indexed for MEDLINE]

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