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Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
Arthritis Res Ther. 2010;12(3):R107. doi: 10.1186/ar3041. Epub 2010 Jun 2.
Arthritis Res Ther. 2010.
PMID: 20525198
Free PMC article.
Inhibition of PDE4 has previously been shown to suppress immune and inflammatory responses, demonstrating PDE4 to be a valid therapeutic target for immune-mediated pathologies. We assessed the anti-inflammatory effects of a …
Inhibition of PDE4 has previously been shown to suppress immune and inflammatory responses, demonstrating …
Apremilast Ameliorates Experimental Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of CD4(+)Foxp3(+) Regulatory T Cells Differentiation.
Chen W, Wang J, Xu Z, Huang F, Qian W, Ma J, Wee HB, Lewis GS, June RR, Schafer PH, Lin J, Zheng SG.
Chen W, et al.
Front Immunol. 2018 Jul 18;9:1662. doi: 10.3389/fimmu.2018.01662. eCollection 2018.
Front Immunol. 2018.
PMID: 30072998
Free PMC article.
Apremilast is a novel phosphodiesterase 4 (PDE4) inhibitor suppressing immune and inflammatory responses. ...To determine whether Apremilast can ameliorate arthritis onset in this model, Apremilast …
Apremilast is a novel phosphodiesterase 4 (PDE4) inhibitor suppressing immune and …
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Apremilast for discoid lupus erythematosus: results of a phase 2, open-label, single-arm, pilot study.
De Souza A, Strober BE, Merola JF, Oliver S, Franks AG Jr.
De Souza A, et al.
J Drugs Dermatol. 2012 Oct;11(10):1224-6.
J Drugs Dermatol. 2012.
PMID: 23134988
Clinical Trial.
BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic inflammatory disorder mediated by Th1 cells. Apremilast is a novel oral PDE4 enzyme inhibitor capable of blocking leukocyte production of IL-12, IL-23, TNF-a, INF- with subsequent sup …
BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic inflammatory disorder mediated by Th1 cells. Apremilast is a nov …
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Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?
Giembycz MA.
Giembycz MA.
Br J Pharmacol. 2008 Oct;155(3):288-90. doi: 10.1038/bjp.2008.297. Epub 2008 Jul 28.
Br J Pharmacol. 2008.
PMID: 18660832
Free PMC article.
PDE4 inhibitors have been in development as a novel anti-inflammatory therapy since the 1980s with asthma and chronic obstructive pulmonary disease (COPD) being primary indications. ...In addition, other approaches are possible that may allow the anti-infl …
PDE4 inhibitors have been in development as a novel anti-inflammatory therapy since the 1980s with asthma and chronic o …
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