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Neuropsychobiology. 1995;31(2):81-8.

Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardized test. An integration of three studies.

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Institute for Human Psychopharmacology, University of Limburg, Maastricht, The Netherlands.


Effects of benzodiazepine (diazepam, lorazepam) and benzodiazepine-like anxiolytics (alpidem, suriclone) and a 5-HT-3 antagonist (ondansetron) on actual driving performance were measured in three double-blind, placebo-controlled studies. Subjects were healthy volunteers in two and anxious patients in the third. Treatments lasted for 8 days. Standardized testing occurred within the first full day and on the last day of treatment. No important differences existed between volunteers' and patients' baseline and/or placebo performances and both groups responded similarly to comparable drugs/doses. Benzodiazepine and benzodiazepine-like anxiolytics produced marked and pervasive driving impairment, which lasted throughout treatment; but ondansetron, none.

[Indexed for MEDLINE]

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