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Pharm Biol. 2017 Dec;55(1):775-781. doi: 10.1080/13880209.2016.1275025.

Antioxidant and antimicrobial activities of ethanol and aqueous extracts from Urtica urens.

Author information

1
a Laboratory of Histology Embryology and Reproductive Biology, Faculty of Medicine of Sfax , University of Sfax , Sfax , Tunisia.
2
b Laboratory of Pharmacology, Faculty of Medicine of Sfax , University of Sfax , Sfax , Tunisia.

Abstract

CONTEXT:

Urtica urens L. (Urticaceae) is an important and commonly used plant for its medicinal and pharmacological properties.

OBJECTIVE:

We analyzed the antioxidant and antimicrobial activities of the leaves of Urtica urens in ethanol (EtOH) and water (WA) solvents, employing standard analytical methods.

MATERIALS AND METHODS:

Polyphenol, flavonoid and tannin content of Urtica urens leaves were determined, after their extraction, using EtOH (70%) and WA extracts as well as the antioxidant (DPPH, ABTS, β-carotene and FRAP) and the antibacterial (via the method of dilution tests) activities of EtOH and WA extracts.

RESULTS:

The 70% EtOH of Urtica urens showed the highest values of total phenolic (31.41 mg GAE/g DW), flavonoids (6.81 mg quercetin/g DW), tannin (8.29 mg GAE/g DW) and TEAC (560 mmol Trolox/g DW), compared to the WA. The results of DPPH for EtOH (95.56%) were higher than that of WA (64.56%) at a concentration of 40 mg/L. The extracts displayed a FRAP 106.23 for EtOH and 30.55 μmol Fe(II)/g DW for WA. The results clearly indicated that EtOH was the strongest radical scavenger (IC50 =245.65 ± 10.2 μg/mL). Ethanol was the most effective with minimum inhibitory concentration (MIC) < 250 μg/mL. WA has no antibacterial activity.

DISCUSSION AND CONCLUSION:

The results indicate that leaves of Urtica urens could be used as natural antioxidant and antimicrobial agents.

KEYWORDS:

Flavonoids; MIC; Polyphenols

PMID:
28084125
PMCID:
PMC6130501
DOI:
10.1080/13880209.2016.1275025
[Indexed for MEDLINE]
Free PMC Article

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