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Nanomedicine (Lond). 2016 Mar;11(6):657-71. doi: 10.2217/nnm.15.217. Epub 2016 Feb 25.

Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species.

Author information

1
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 333, Taiwan.
2
Research Center for Industry of Human Ecology, Chang Gung University of Science & Technology, Kweishan, Taoyuan, Taiwan.
3
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
4
Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, USA.
5
Department of Cosmetic Science, Chang Gung University of Science & Technology, Kweishan, Taoyuan, Taiwan.
6
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan.
7
Immunology Consortium, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.

Abstract

AIM:

Here we evaluated the antibacterial efficacy of soyaethyl morpholinium ethosulfate (SME) micelles as an inherent bactericide against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA).

METHODOLOGY:

The antimicrobial activity was examined by in vitro culture model and murine model of skin infection. Cationic micelles formed by benzalkonium chloride or cetylpyridinium chloride were used for comparison.

RESULTS:

The minimum inhibitory concentration and minimum bactericidal concentration against S. aureus and MRSA were 1.71-3.42 and 1.71-6.84 μg/ml, respectively. Topical administration of SME micelles significantly decreased the cutaneous infection and MRSA load in mice. The killing of bacteria was caused by direct cell wall/membrane rupture. SME micelles also penetrated into the bacteria to elicit a Fenton reaction and oxidative stress.

CONCLUSION:

SME micelles have potential as antimicrobial agents due to their lethal effect against S. aureus and MRSA with a low toxicity to mammalian cells.

KEYWORDS:

antimicrobial; methicillin-resistant S. aureus; micelle; skin; soyaethyl morpholinium ethosulfate

PMID:
26911580
DOI:
10.2217/nnm.15.217
[Indexed for MEDLINE]

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