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Acta Pharmacol Sin. 2015 Jun;36(6):676-9. doi: 10.1038/aps.2015.24. Epub 2015 May 18.

Anti-tumor activities of active ingredients in Compound Kushen Injection.

Author information

1
1] Beijing Zhendong Guangming Pharmaceutical Research Institute Co Ltd, Beijing 100120, China [2] Shanxi Zhendong Pharmaceutical Co Ltd, Changzhi 047100, China [3] Gastroenterology Department, the Second People's Hospital of Zhuhai, Zhuhai 519000, China.
2
1] Beijing Zhendong Guangming Pharmaceutical Research Institute Co Ltd, Beijing 100120, China [2] Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
3
Beijing Zhendong Guangming Pharmaceutical Research Institute Co Ltd, Beijing 100120, China.
4
Department of Respiration, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China.
5
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
6
Shanxi Zhendong Pharmaceutical Co Ltd, Changzhi 047100, China.
7
1] Shanxi Zhendong Pharmaceutical Co Ltd, Changzhi 047100, China [2] Department of Pharmacy, Chang Zhi Medical College, Changzhi 046000, China.

Abstract

Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Kushen and Baituling (Rhizoma Smilacis Glabrae). The main principles of CKI are matrine (MT) and oxymatrine (OMT) that exhibit a variety of pharmacological activities, including anti-inflammatory, anti-allergic, anti-viral, anti-fibrotic and cardiovascular protective effects. Recent evidence shows that these compounds also produce anti-cancer actions, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy- and/or radiotherapy-induced toxicity when combined with chemotherapeutic drugs. In this review, we summarize recent progress in studying the anti-cancer activities of MT, OMT and CKI and their potential molecular targets, which provide clues and references for further study.

PMID:
25982630
PMCID:
PMC4594177
DOI:
10.1038/aps.2015.24
[Indexed for MEDLINE]
Free PMC Article

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