Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Fitoterapia. 2015 Apr;102:115-9. doi: 10.1016/j.fitote.2015.02.010. Epub 2015 Feb 23.

Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium.

Author information

1
Graduate Institute of Medical Science, National Defense Medical Center, No. 161, Sec. 6, Minchuan East Road, Neihu District, Taipei City 114, Taiwan, ROC; School of Pharmacy, National Defense Medical Center, No. 161, Sec. 6, Minchuan East Road, Neihu District, Taipei City 114, Taiwan, ROC.
2
Department of Pathology, Tri-Service General Hospital, No. 325, Sec. 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan, ROC.
3
LanTyng Biotech, Co., Ltd. Taipei, Taiwan, ROC.
4
Graduate Institute of Life Science, National Defense Medical Center, No. 161, Sec. 6, Minchuan East Road, Neihu District, Taipei City 114, Taiwan, ROC.
5
School of Pharmacy, National Defense Medical Center, No. 161, Sec. 6, Minchuan East Road, Neihu District, Taipei City 114, Taiwan, ROC. Electronic address: wlchang@mail.ndmctsgh.edu.tw.

Abstract

Three new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata (Polyporaceae) mycelium. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analyses. These ubiquinones exhibited selective cytotoxicities against five human cancer cell lines (CT26, A549, HepG2, PC3 and DU-145) with IC50 values ranging from 0.01 to 1.79μΜ.

KEYWORDS:

Antrocamol LT1; Antrocamol LT2; Antrocamol LT3; Antrodia camphorata; Cytotoxicity; Ubiquinone derivative

PMID:
25721423
DOI:
10.1016/j.fitote.2015.02.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center