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Genes Dev. 2017 Sep 1;31(17):1715-1716. doi: 10.1101/gad.306837.117.

Another case for diet restriction: TAp73-expressing medulloblastomas are stunted by glutamine withdrawal.

Author information

1
Department of Molecular Oncology, Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.

Abstract

Medulloblastomas are among the most common malignant brain cancers in the pediatric population and consist of at least four distinct subgroups with unique molecular and genetic features and clinical outcomes. In this issue of Genes & Development, Niklison-Chirou and colleagues (pp. 1738-1753) identify the p53 family member and p73 isoform TAp73 as a crucial factor causing glutamine addiction in aggressive medulloblastomas. Their findings pave the way for the use of glutamine restriction as an adjuvant treatment for TAp73-expressing medulloblastomas.

KEYWORDS:

glutamine; medulloblastoma; metabolomics; p73

PMID:
28982757
PMCID:
PMC5666670
DOI:
10.1101/gad.306837.117
[Indexed for MEDLINE]
Free PMC Article

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