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Items: 15


Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.

Basch ML, Brown RM 2nd, Jen HI, Semerci F, Depreux F, Edlund RK, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK.

Elife. 2016 Dec 14;5. pii: e19921. doi: 10.7554/eLife.19921.


Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.

Doetzlhofer A, Avraham KB.

Semin Cell Dev Biol. 2017 May;65:69-79. doi: 10.1016/j.semcdb.2016.11.002. Epub 2016 Nov 9. Review.


Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation.

Evsen L, Doetzlhofer A.

J Vis Exp. 2016 Apr 17;(110). doi: 10.3791/53864.


Canonical Notch signaling plays an instructive role in auditory supporting cell development.

Campbell DP, Chrysostomou E, Doetzlhofer A.

Sci Rep. 2016 Jan 20;6:19484. doi: 10.1038/srep19484.


The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.

Golden EJ, Benito-Gonzalez A, Doetzlhofer A.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73. doi: 10.1073/pnas.1501077112. Epub 2015 Jul 2.


Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling.

Benito-Gonzalez A, Doetzlhofer A.

J Neurosci. 2014 Sep 17;34(38):12865-76. doi: 10.1523/JNEUROSCI.1494-14.2014.


Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea.

Korrapati S, Roux I, Glowatzki E, Doetzlhofer A.

PLoS One. 2013 Aug 30;8(8):e73276. doi: 10.1371/journal.pone.0073276. eCollection 2013.


Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti.

Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N.

Dev Cell. 2009 Jan;16(1):58-69. doi: 10.1016/j.devcel.2008.11.008.


p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis.

Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pirvola U.

J Neurosci. 2007 Feb 7;27(6):1434-44.


Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells.

White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N.

Nature. 2006 Jun 22;441(7096):984-7.


Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea.

Doetzlhofer A, White P, Lee YS, Groves A, Segil N.

Brain Res. 2006 May 26;1091(1):282-8. Epub 2006 Apr 17.


In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme.

Doetzlhofer A, White PM, Johnson JE, Segil N, Groves AK.

Dev Biol. 2004 Aug 15;272(2):432-47.


Math1-driven GFP expression in the developing nervous system of transgenic mice.

Lumpkin EA, Collisson T, Parab P, Omer-Abdalla A, Haeberle H, Chen P, Doetzlhofer A, White P, Groves A, Segil N, Johnson JE.

Gene Expr Patterns. 2003 Aug;3(4):389-95.


The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.

Lagger G, Doetzlhofer A, Schuettengruber B, Haidweger E, Simboeck E, Tischler J, Chiocca S, Suske G, Rotheneder H, Wintersberger E, Seiser C.

Mol Cell Biol. 2003 Apr;23(8):2669-79.


Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification.

Schuettengruber B, Doetzlhofer A, Kroboth K, Wintersberger E, Seiser C.

J Biol Chem. 2003 Jan 17;278(3):1784-93. Epub 2002 Oct 30.

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