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Scand J Med Sci Sports. 2016 Nov;26(11):1313-1320. doi: 10.1111/sms.12587. Epub 2015 Dec 4.

Androgen receptor gene polymorphism influence fat accumulation: A longitudinal study from adolescence to adult age.

Author information

1
Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
2
Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
3
Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
4
Canary Islands Cancer Research Institute (ICIC), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
5
Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. lopezcalbet@gmail.com.
6
Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. lopezcalbet@gmail.com.

Abstract

To determine the influence of androgen receptor CAG and GGN repeat polymorphisms on fat mass and maximal fat oxidation (MFO), CAG and GGN repeat lengths were measured in 128 young boys, from which longitudinal data were obtained in 45 of them [mean ± SD: 12.8 ± 3.6 years old at recruitment, and 27.0 ± 4.8 years old at adult age]. Subjects were grouped as CAG short (CAGS ) if harboring repeat lengths ≤  21, the rest as CAG long (CAGL ); and GGN short (GGNS ) if GGN repeat lengths ≤  23, or long if >  23 (GGNL ). CAGS and GGNS were associated with lower adiposity than CAGL or GGNL (P < 0.05). There was an association between the logarithm of CAG repeats polymorphism and the changes of body mass (r = 0.34, P = 0.03). At adult age, CAGS men showed lower accumulation of total body and trunk fat mass, and lower resting metabolic rate (RMR) and MFO per kg of total lean mass compared with CAGL (P < 0.05). GGNS men also showed lower percentage of body fat (P < 0.05). In summary, androgen receptor CAG and GGN repeat polymorphisms are associated with RMR, MFO, fat mass, and its regional distribution in healthy male adolescents, influencing fat accumulation from adolescence to adult age.

KEYWORDS:

AR CAG polymorphisms; AR GGN polymorphisms; adolescent; fat mass

PMID:
26634957
DOI:
10.1111/sms.12587
[Indexed for MEDLINE]

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