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  • Showing results for andra ss, charisiadis p, arora m, van vliet ostaptchouk jv, makris kc. biomonitoring of human exposures to chlorinated. Your search for Andra SS, Charisiadis P, Arora M, van Vilet-Ostaptchouk JV, Makris KC. Biomonitoring of human exposures to chlorinated retrieved no results.
Environ Int. 2015 Dec;85:352-79. doi: 10.1016/j.envint.2015.09.011. Epub 2015 Oct 30.

Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A.

Author information

1
Exposure Biology, Lautenberg Environmental Health Sciences Laboratory, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: syam.andra@mssm.edu.
2
Water and Health Laboratory, Cyprus International Institute for Environmental and Public Health in association with Harvard School of Public Health, Cyprus University of Technology, Limassol, Cyprus.
3
Exposure Biology, Lautenberg Environmental Health Sciences Laboratory, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Faculty of Dentistry, University of Sydney, Sydney, NSW, Australia.
4
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700, RB, The Netherlands.
5
Water and Health Laboratory, Cyprus International Institute for Environmental and Public Health in association with Harvard School of Public Health, Cyprus University of Technology, Limassol, Cyprus; Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address: konstantinos.makris@cut.ac.cy.

Abstract

The high reactivity of bisphenol A (BPA) with disinfectant chlorine is evident in the instantaneous formation of chlorinated BPA derivatives (ClxBPA) in various environmental media that show increased estrogen-activity when compared with that of BPA. The documented health risks associated with BPA exposures have led to the gradual market entry of BPA structural analogs, such as bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), etc. A suite of exposure sources to ClxBPA and BPA analogs in the domestic environment is anticipated to drive the nature and range of halogenated BPA derivatives that can form when residual BPA comes in contact with disinfectant in tap water and/or consumer products. The primary objective of this review was to survey all available studies reporting biomonitoring protocols of ClxBPA and structural BPA analogs (BPS, BPF, BPB, etc.) in human matrices. Focus was paid on describing the analytical methodologies practiced for the analysis of ClxBPA and BPA analogs using hyphenated chromatography and mass spectrometry techniques, because current methodologies for human matrices are complex. During the last decade, an increasing number of ecotoxicological, cell-culture and animal-based and human studies dealing with ClxBPA exposure sources and routes of exposure, metabolism and toxicity have been published. Up to date findings indicated the association of ClxBPA with metabolic conditions, such as obesity, lipid accumulation, and type 2 diabetes mellitus, particularly in in-vitro and in-vivo studies. We critically discuss the limitations, research needs and future opportunities linked with the inclusion of ClxBPA and BPA analogs into exposure assessment protocols of relevant epidemiological studies.

KEYWORDS:

BPA analogs; BPA free; Biomonitoring; Bisphenol A; Chlorinated derivatives; Disinfection; Emerging contaminants; Human exposure; Mass spectrometry; Metabolites; analogs

PMID:
26521216
DOI:
10.1016/j.envint.2015.09.011
[Indexed for MEDLINE]

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