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Curr Opin Pediatr. 2016 Apr;28(2):221-7. doi: 10.1097/MOP.0000000000000327.

The tooth exposome in children's health research.

Author information

1
aSenator Frank R Lautenberg Environmental Health Sciences Laboratory, Department of Preventive Medicine, Division of Environmental Health, Icahn School of Medicine at Mount Sinai, New York City, New York, USA *Syam S. Andra, Christine Austin, and Manish Arora contributed equally to the writing of this article.

Abstract

PURPOSE OF REVIEW:

The exposome concept proposes a comprehensive assessment of environmental exposures from the prenatal period onwards. However, determining exposure timing, especially over the prenatal period, is a major challenge in environmental epidemiologic studies.

RECENT FINDINGS:

For decades, teeth have been used to estimate long-term cumulative exposure to metals. Recently developed high-dimensional analytical methods, which combine sophisticated histological and chemical analysis to precisely sample tooth layers that correspond to specific life stages, have the potential to reconstruct the exposome in the second and third trimesters of prenatal development and during early childhood.

SUMMARY:

A retrospective temporal exposomic approach that precisely measures exposure intensity 'and timing' during prenatal and early childhood development would substantially aid epidemiologic investigations, particularly case-control studies of rare health outcomes.

PMID:
26859286
PMCID:
PMC4949598
DOI:
10.1097/MOP.0000000000000327
[Indexed for MEDLINE]
Free PMC Article

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