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Items: 1 to 20 of 66

1.

Novel multi-target directed ligand-based strategies for reducing neuroinflammation in Alzheimer's disease.

Wenzel TJ, Klegeris A.

Life Sci. 2018 Jun 22. pii: S0024-3205(18)30364-3. doi: 10.1016/j.lfs.2018.06.025. [Epub ahead of print] Review.

PMID:
29940242
2.

Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM).

Schindler SM, Frank MG, Annis JL, Maier SF, Klegeris A.

Mol Cell Neurosci. 2018 Jun;89:71-79. doi: 10.1016/j.mcn.2018.04.005. Epub 2018 Apr 17.

PMID:
29678518
3.

Emerging roles of microglial cathepsins in neurodegenerative disease.

Lowry JR, Klegeris A.

Brain Res Bull. 2018 May;139:144-156. doi: 10.1016/j.brainresbull.2018.02.014. Epub 2018 Feb 15. Review.

PMID:
29454581
4.

Extracellular cytochrome c as an intercellular signaling molecule regulating microglial functions.

Gouveia A, Bajwa E, Klegeris A.

Biochim Biophys Acta. 2017 Sep;1861(9):2274-2281. doi: 10.1016/j.bbagen.2017.06.017. Epub 2017 Jun 23.

PMID:
28652078
5.

Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors.

Spielman LJ, Gibson DL, Klegeris A.

Eur J Cell Biol. 2017 May;96(3):240-253. doi: 10.1016/j.ejcb.2017.03.004. Epub 2017 Mar 8.

PMID:
28336086
6.

Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer's and Parkinson's Diseases.

McKenzie JA, Spielman LJ, Pointer CB, Lowry JR, Bajwa E, Lee CW, Klegeris A.

Curr Aging Sci. 2017;10(3):158-176. doi: 10.2174/1874609810666170315113244. Review.

PMID:
28302047
7.

High Glucose Enhances Neurotoxicity and Inflammatory Cytokine Secretion by Stimulated Human Astrocytes.

Bahniwal M, Little JP, Klegeris A.

Curr Alzheimer Res. 2017;14(7):731-741. doi: 10.2174/1567205014666170117104053.

PMID:
28124586
8.

The effects of voluntary wheel running on neuroinflammatory status: Role of monocyte chemoattractant protein-1.

Spielman LJ, Estaki M, Ghosh S, Gibson DL, Klegeris A.

Mol Cell Neurosci. 2017 Mar;79:93-102. doi: 10.1016/j.mcn.2016.12.009. Epub 2017 Jan 11.

PMID:
28088610
9.

Cardiolipin in Central Nervous System Physiology and Pathology.

Pointer CB, Klegeris A.

Cell Mol Neurobiol. 2017 Oct;37(7):1161-1172. doi: 10.1007/s10571-016-0458-9. Epub 2016 Dec 30. Review.

PMID:
28039536
10.

Elucidating the link between the modifiable risk factors of Alzheimer's disease and neuroinflammation.

Schindler SM, Klegeris A.

Neurodegener Dis Manag. 2016 Oct;6(5):375-84. doi: 10.2217/nmt-2016-0028. Epub 2016 Sep 7.

PMID:
27600142
11.

Physical activity and exercise attenuate neuroinflammation in neurological diseases.

Spielman LJ, Little JP, Klegeris A.

Brain Res Bull. 2016 Jul;125:19-29. doi: 10.1016/j.brainresbull.2016.03.012. Epub 2016 Mar 26. Review.

PMID:
27021169
12.

Insulin Modulates In Vitro Secretion of Cytokines and Cytotoxins by Human Glial Cells.

Spielman LJ, Bahniwal M, Little JP, Walker DG, Klegeris A.

Curr Alzheimer Res. 2015;12(7):684-93.

PMID:
26159205
13.

A new look at auranofin, dextromethorphan and rosiglitazone for reduction of glia-mediated inflammation in neurodegenerative diseases.

Madeira JM, Schindler SM, Klegeris A.

Neural Regen Res. 2015 Mar;10(3):391-3. doi: 10.4103/1673-5374.153686. Review.

14.

Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst.

Madeira JM, Bajwa E, Stuart MJ, Hashioka S, Klegeris A.

J Neuroimmunol. 2014 Nov 15;276(1-2):71-9. doi: 10.1016/j.jneuroim.2014.08.615. Epub 2014 Aug 19.

PMID:
25175064
15.

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration.

Spielman LJ, Little JP, Klegeris A.

J Neuroimmunol. 2014 Aug 15;273(1-2):8-21. doi: 10.1016/j.jneuroim.2014.06.004. Epub 2014 Jun 12. Review.

PMID:
24969117
16.

Microparticles: a new perspective in central nervous system disorders.

Schindler SM, Little JP, Klegeris A.

Biomed Res Int. 2014;2014:756327. doi: 10.1155/2014/756327. Epub 2014 Apr 9. Review.

17.

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia.

Little JP, Simtchouk S, Schindler SM, Villanueva EB, Gill NE, Walker DG, Wolthers KR, Klegeris A.

Mol Cell Neurosci. 2014 May;60:88-96. doi: 10.1016/j.mcn.2014.04.003. Epub 2014 Apr 23.

PMID:
24769106
18.

Globular adiponectin induces a pro-inflammatory response in human astrocytic cells.

Wan Z, Mah D, Simtchouk S, Klegeris A, Little JP.

Biochem Biophys Res Commun. 2014 Mar 28;446(1):37-42. doi: 10.1016/j.bbrc.2014.02.077. Epub 2014 Feb 25.

PMID:
24582565
19.

Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes.

Hashioka S, Wang YF, Little JP, Choi HB, Klegeris A, McGeer PL, McLarnon JG.

BMC Neurosci. 2014 Jan 22;15:18. doi: 10.1186/1471-2202-15-18.

20.

Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease.

Ryu JK, Little JP, Klegeris A, Jantaratnotai N, McLarnon JG.

Curr Alzheimer Res. 2013 Mar;10(3):252-60.

PMID:
23534534

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