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Clin Exp Gastroenterol. 2010;3:171-7. doi: 10.2147/CEG.S15340. Epub 2010 Dec 6.

Amino acid-responsive Crohn's disease: a case study.

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1
Stein Orthopedic Associates, Plantation, FL, USA;

Abstract

PURPOSE:

This paper reviews the clinical course of a case of severe Crohn's disease and discusses the scientific ramifications of a novel treatment approach.

PATIENTS AND METHODS:

A case study of a 37-year-old male with a 22-year history of Crohn's disease whose clinical course had experienced no sustained remissions. The patient was treated with a protocol that utilized serotonin and dopamine amino acid precursors administered under the guidance of organic cation transporter assay interpretation.

RESULTS:

Within 5 days of achieving the necessary balance of serotonin and dopamine, the patient experienced remission of symptoms. This remission has been sustained without the use of any Crohn's disease medications.

CONCLUSION:

In Crohn's disease, it is known that there is an increase of both synthesis and tissue levels of serotonin in specific locations. It is asserted that this is prima facie evidence of a significant imbalance in the serotonin-dopamine system, leading to serotonin toxicity. The hypothesis formulated is that improperly balanced serotonin and dopamine transport, synthesis, and metabolism is a primary defect contributing to the pathogenesis of Crohn's disease.

KEYWORDS:

OCT; dopamine; organic cation transporters; serotonin

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