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Items: 1 to 20 of 63

1.

Dry Age-Related Macular Degeneration Pharmacology.

Wright CB, Ambati J.

Handb Exp Pharmacol. 2016 Nov 30. [Epub ahead of print]

PMID:
27900609
2.

A Revised Hemodynamic Theory of Age-Related Macular Degeneration.

Gelfand BD, Ambati J.

Trends Mol Med. 2016 Aug;22(8):656-70. doi: 10.1016/j.molmed.2016.06.009. Epub 2016 Jul 13. Review.

PMID:
27423265
3.

Intravenous immune globulin suppresses angiogenesis in mice and humans.

Yasuma R, Cicatiello V, Mizutani T, Tudisco L, Kim Y, Tarallo V, Bogdanovich S, Hirano Y, Kerur N, Li S, Yasuma T, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ambati BK, Helmers SB, Lundberg IE, Viklicky O, Leusen JH, Verbeek JS, Gelfand BD, Bastos-Carvalho A, De Falco S, Ambati J.

Signal Transduct Target Ther. 2016;1. pii: 15002. Epub 2016 Jan 28.

4.

Human IgG1 antibodies suppress angiogenesis in a target-independent manner.

Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J.

Signal Transduct Target Ther. 2016;1. pii: 15001. Epub 2016 Jan 28.

5.

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice.

Mizutani T, Fowler BJ, Kim Y, Yasuma R, Krueger LA, Gelfand BD, Ambati J.

Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7122-9. doi: 10.1167/iovs.15-17440.

6.

Complement Activation and Inhibition in Retinal Diseases.

Kleinman ME, Ambati J.

Dev Ophthalmol. 2016;55:46-56. doi: 10.1159/000431141. Epub 2015 Oct 26. Review.

PMID:
26501209
7.

Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.

Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH, Núñez G, Georgel P, Dunaief JL, Ambati J.

Cell Rep. 2015 Jun 23;11(11):1686-93. doi: 10.1016/j.celrep.2015.05.023. Epub 2015 Jun 11.

8.

Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models.

Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, De Falco S.

Oncotarget. 2015 Apr 30;6(12):10563-76.

9.

IL-18 is not therapeutic for neovascular age-related macular degeneration.

Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton DR, Ambati J.

Nat Med. 2014 Dec;20(12):1372-5. doi: 10.1038/nm.3671. No abstract available.

10.

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.

Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J.

Science. 2014 Nov 21;346(6212):1000-3. doi: 10.1126/science.1261754.

11.

DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16082-7. doi: 10.1073/pnas.1403814111. Epub 2014 Oct 27.

12.

TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.

Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton DR, Kirschning CJ, Gelfand BD, Ambati J.

Invest Ophthalmol Vis Sci. 2013 Nov 11;54(12):7395-401. doi: 10.1167/iovs.13-12500.

13.

Retinal angiogenesis suppression through small molecule activation of p53.

Chavala SH, Kim Y, Tudisco L, Cicatiello V, Milde T, Kerur N, Claros N, Yanni S, Guaiquil VH, Hauswirth WW, Penn JS, Rafii S, De Falco S, Lee TC, Ambati J.

J Clin Invest. 2013 Oct;123(10):4170-81. doi: 10.1172/JCI67315. Epub 2013 Sep 9.

14.

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1.

Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuquerque R, Baehr W, Thomas K, Li DY, Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Ambati J, Ambati BK.

Elife. 2013 Jun 18;2:e00324. doi: 10.7554/eLife.00324.

15.

Immunology of age-related macular degeneration.

Ambati J, Atkinson JP, Gelfand BD.

Nat Rev Immunol. 2013 Jun;13(6):438-51. doi: 10.1038/nri3459. Review.

16.

Targeted intraceptor nanoparticle therapy reduces angiogenesis and fibrosis in primate and murine macular degeneration.

Luo L, Zhang X, Hirano Y, Tyagi P, Barabás P, Uehara H, Miya TR, Singh N, Archer B, Qazi Y, Jackman K, Das SK, Olsen T, Chennamaneni SR, Stagg BC, Ahmed F, Emerson L, Zygmunt K, Whitaker R, Mamalis C, Huang W, Gao G, Srinivas SP, Krizaj D, Baffi J, Ambati J, Kompella UB, Ambati BK.

ACS Nano. 2013 Apr 23;7(4):3264-75. doi: 10.1021/nn305958y. Epub 2013 Mar 20.

17.

Clocking in on diabetic retinopathy.

Kleinman ME, Ambati J.

Diabetes. 2013 Jan;62(1):29-30. doi: 10.2337/db12-1151. No abstract available.

18.

Mammary cancer gene therapy targeting lymphangiogenesis: VEGF-C siRNA and soluble VEGF receptor-2, a splicing variant.

Shibata MA, Ambati J, Shibata E, Yoshidome K, Harada-Shiba M.

Med Mol Morphol. 2012 Dec;45(4):179-84. doi: 10.1007/s00795-012-0576-5. Epub 2012 Dec 7. Review.

PMID:
23224595
19.

Inhibition of choroidal and corneal pathologic neovascularization by Plgf1-de gene transfer.

Tarallo V, Bogdanovich S, Hirano Y, Tudisco L, Zentilin L, Giacca M, Ambati J, De Falco S.

Invest Ophthalmol Vis Sci. 2012 Dec 5;53(13):7989-96. doi: 10.1167/iovs.12-10658.

20.

Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR).

Uehara H, Cho Y, Simonis J, Cahoon J, Archer B, Luo L, Das SK, Singh N, Ambati J, Ambati BK.

FASEB J. 2013 Jan;27(1):76-85. doi: 10.1096/fj.12-213835. Epub 2012 Sep 20.

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