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See 1 citation in Am J Transplant 2014:

Am J Transplant. 2014 Dec;14(12):2846-54. doi: 10.1111/ajt.12927. Epub 2014 Oct 3.

In situ normothermic regional perfusion for controlled donation after circulatory death--the United Kingdom experience.

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Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.


Organs recovered from donors after circulatory death (DCD) suffer warm ischemia before cold storage which may prejudice graft survival and result in a greater risk of complications after transplant. A period of normothermic regional perfusion (NRP) in the donor may reverse these effects and improve organ function. Twenty-one NRP retrievals from Maastricht category III DCD donors were performed at three UK centers. NRP was established postasystole via aortic and caval cannulation and maintained for 2 h. Blood gases and biochemistry were monitored to assess organ function. Sixty-three organs were recovered. Forty-nine patients were transplanted. The median time from asystole to NRP was 16 min (range 10-23 min). Thirty-two patients received a kidney transplant. The median cold ischemia time was 12 h 30 min (range 5 h 25 min-18 h 22 min). The median creatinine at 3 and 12 months was 107 µmol/L (range 72-222) and 121 µmol/L (range 63-157), respectively. Thirteen (40%) recipients had delayed graft function and four lost the grafts. Eleven patients received a liver transplant. The first week median peak ALT was 389 IU/L (range 58-3043). One patient had primary nonfunction. Two combined pancreas-kidney transplants, one islet transplant and three double lung transplants were performed with primary function. NRP in DCD donation facilitates organ recovery and may improve short-term outcomes.


Clinical research/practice; donors and donation; donors and donation: donation after circulatory death (DCD); extra-corporeal membrane oxygenation (ECMO); kidney transplantation/nephrology; liver transplantation/hepatology; organ perfusion and preservation; organ procurement; organ transplantation in general

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