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Psychol Med. 2015 May;45(7):1379-88. doi: 10.1017/S0033291714002451. Epub 2014 Nov 17.

Genome-wide scan demonstrates significant linkage for male sexual orientation.

Author information

1
Department of Psychiatry and Behavioral Sciences,NorthShore University HealthSystem Research Institute,Evanston,IL,USA.
2
Department of Human Genetics,University of Miami,Miami,FL,USA.
3
Department of Psychology,Pennsylvania State University,University Park,PA,USA.
4
Department of Psychology,University of Essex,Colchester,England,UK.
5
Department of Psychiatry and Behavioral Neuroscience,University of Chicago,Chicago,IL,USA.
6
Department of Psychiatry,Icahn School of Medicine at Mount Sinai,Elmhurst,NY,USA.
7
Department of Sociomedical Sciences,Mailman School of Public Health, Columbia University,New York,NY,USA.
8
Department of Psychology,Northwestern University,Evanston,IL,USA.

Abstract

BACKGROUND:

Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28.

METHOD:

We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date.

RESULTS:

We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research.

CONCLUSIONS:

Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.

KEYWORDS:

male sexual orientation.

PMID:
25399360
DOI:
10.1017/S0033291714002451
[Indexed for MEDLINE]

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