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Items: 1 to 20 of 205

1.

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals.

Deelen J, Kettunen J, Fischer K, van der Spek A, Trompet S, Kastenmüller G, Boyd A, Zierer J, van den Akker EB, Ala-Korpela M, Amin N, Demirkan A, Ghanbari M, van Heemst D, Ikram MA, van Klinken JB, Mooijaart SP, Peters A, Salomaa V, Sattar N, Spector TD, Tiemeier H, Verhoeven A, Waldenberger M, Würtz P, Davey Smith G, Metspalu A, Perola M, Menni C, Geleijnse JM, Drenos F, Beekman M, Jukema JW, van Duijn CM, Slagboom PE.

Nat Commun. 2019 Aug 20;10(1):3346. doi: 10.1038/s41467-019-11311-9.

2.

Exome sequencing of Finnish isolates enhances rare-variant association power.

Locke AE, Steinberg KM, Chiang CWK, Service SK, Havulinna AS, Stell L, Pirinen M, Abel HJ, Chiang CC, Fulton RS, Jackson AU, Kang CJ, Kanchi KL, Koboldt DC, Larson DE, Nelson J, Nicholas TJ, Pietilä A, Ramensky V, Ray D, Scott LJ, Stringham HM, Vangipurapu J, Welch R, Yajnik P, Yin X, Eriksson JG, Ala-Korpela M, Järvelin MR, Männikkö M, Laivuori H; FinnGen Project, Dutcher SK, Stitziel NO, Wilson RK, Hall IM, Sabatti C, Palotie A, Salomaa V, Laakso M, Ripatti S, Boehnke M, Freimer NB.

Nature. 2019 Aug;572(7769):323-328. doi: 10.1038/s41586-019-1457-z. Epub 2019 Jul 31.

PMID:
31367044
3.

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression.

Männistö V, Kaminska D, Kärjä V, Tiainen M, de Mello VD, Hanhineva K, Soininen P, Ala-Korpela M, Pihlajamäki J.

Liver Int. 2019 Jun 14. doi: 10.1111/liv.14174. [Epub ahead of print]

PMID:
31199045
4.

Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease.

Jia Q, Han Y, Huang P, Woodward NC, Gukasyan J, Kettunen J, Ala-Korpela M, Anufrieva O, Wang Q, Perola M, Raitakari O, Lehtimäki T, Viikari J, Järvelin MR, Boehnke M, Laakso M, Mohlke KL, Fiehn O, Wang Z, Tang WHW, Hazen SL, Hartiala JA, Allayee H.

J Am Heart Assoc. 2019 May 21;8(10):e011922. doi: 10.1161/JAHA.119.011922.

5.

Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum.

Kuusisto S, Holmes MV, Ohukainen P, Kangas AJ, Karsikas M, Tiainen M, Perola M, Salomaa V, Kettunen J, Ala-Korpela M.

Clin Chem. 2019 Aug;65(8):1042-1050. doi: 10.1373/clinchem.2018.299222. Epub 2019 Apr 17.

PMID:
30996052
6.

The culprit is the carrier, not the loads: cholesterol, triglycerides and apolipoprotein B in atherosclerosis and coronary heart disease.

Ala-Korpela M.

Int J Epidemiol. 2019 Apr 9. pii: dyz068. doi: 10.1093/ije/dyz068. [Epub ahead of print] No abstract available.

PMID:
30968109
7.

A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density.

Kemp JP, Sayers A, Fraser WD, Davey Smith G, Ala-Korpela M, Evans DM, Tobias JH.

J Bone Miner Res. 2019 Jul;34(7):1306-1313. doi: 10.1002/jbmr.3697. Epub 2019 Mar 18.

PMID:
30882941
8.

Commentary: Data-driven subgrouping in epidemiology and medicine.

Ala-Korpela M.

Int J Epidemiol. 2019 Apr 1;48(2):374-376. doi: 10.1093/ije/dyz040. No abstract available.

PMID:
30874726
9.

Genetic and environmental perturbations lead to regulatory decoherence.

Lea A, Subramaniam M, Ko A, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Mononen N, Raitakari OT, Ala-Korpela M, Pajukanta P, Zaitlen N, Ayroles JF.

Elife. 2019 Mar 5;8. pii: e40538. doi: 10.7554/eLife.40538.

10.

What is 'LDL cholesterol'?

Holmes MV, Ala-Korpela M.

Nat Rev Cardiol. 2019 Apr;16(4):197-198. doi: 10.1038/s41569-019-0157-6. No abstract available.

PMID:
30700860
11.

Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics.

Tynkkynen T, Wang Q, Ekholm J, Anufrieva O, Ohukainen P, Vepsäläinen J, Männikkö M, Keinänen-Kiukaanniemi S, Holmes MV, Goodwin M, Ring S, Chambers JC, Kooner J, Järvelin MR, Kettunen J, Hill M, Davey Smith G, Ala-Korpela M.

Int J Epidemiol. 2019 Jun 1;48(3):978-993. doi: 10.1093/ije/dyy287.

12.

The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study.

Karjalainen JP, Mononen N, Hutri-Kähönen N, Lehtimäki M, Juonala M, Ala-Korpela M, Kähönen M, Raitakari O, Lehtimäki T.

Sci Rep. 2019 Jan 24;9(1):458. doi: 10.1038/s41598-018-36450-9.

13.

Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients.

Kettunen J, Ritchie SC, Anufrieva O, Lyytikäinen LP, Hernesniemi J, Karhunen PJ, Kuukasjärvi P, Laurikka J, Kähönen M, Lehtimäki T, Havulinna AS, Salomaa V, Männistö S, Ala-Korpela M, Perola M, Inouye M, Würtz P.

Circ Genom Precis Med. 2018 Nov;11(11):e002234. doi: 10.1161/CIRCGEN.118.002234.

PMID:
30571186
14.

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment.

Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood IY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Davey Smith G, Sattar N, Butterworth A, Würtz P.

Circulation. 2018 Nov 27;138(22):2499-2512. doi: 10.1161/CIRCULATIONAHA.118.034942. Epub 2018 Aug 15.

PMID:
30524137
15.

Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment

Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood LY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Smith GD, Sattar N, Butterworth A, Würtz P.

Circulation. 2018 Nov 27;138(22):2499–2512.

16.

Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial.

Beynon RA, Richmond RC, Santos Ferreira DL, Ness AR, May M, Smith GD, Vincent EE, Adams C, Ala-Korpela M, Würtz P, Soidinsalo S, Metcalfe C, Donovan JL, Lane AJ, Martin RM; ProtecT Study Group; PRACTICAL consortium.

Int J Cancer. 2019 Apr 15;144(8):1918-1928. doi: 10.1002/ijc.31929. Epub 2018 Dec 7.

17.

Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.

Barrios C, Zierer J, Würtz P, Haller T, Metspalu A, Gieger C, Thorand B, Meisinger C, Waldenberger M, Raitakari O, Lehtimäki T, Otero S, Rodríguez E, Pedro-Botet J, Kähönen M, Ala-Korpela M, Kastenmüller G, Spector TD, Pascual J, Menni C.

Sci Rep. 2018 Oct 15;8(1):15249. doi: 10.1038/s41598-018-33507-7.

18.

Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts - CORRIGENDUM.

Ramsay H, Barnett JH, Murray GK, Miettunen J, Mäki P, Järvelin MR, Smith GD, Ala-Korpela M, Veijola J.

Psychol Med. 2018 Nov;48(15):2628. doi: 10.1017/S0033291718002192. Epub 2018 Aug 30. No abstract available.

PMID:
30157972
19.

Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts.

Ramsay H, Barnett JH, Murray GK, Miettunen J, Mäki P, Järvelin MR, Smith GD, Ala-Korpela M, Veijola J.

Psychol Med. 2018 Nov;48(15):2609-2623. doi: 10.1017/S0033291718001794. Epub 2018 Jul 24. Erratum in: Psychol Med. 2018 Nov;48(15):2628.

PMID:
30039772
20.

Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies.

Akbaraly T, Würtz P, Singh-Manoux A, Shipley MJ, Haapakoski R, Lehto M, Desrumaux C, Kähönen M, Lehtimäki T, Mikkilä V, Hingorani A, Humphries SE, Kangas AJ, Soininen P, Raitakari O, Ala-Korpela M, Kivimäki M.

Sci Rep. 2018 Jun 5;8(1):8620. doi: 10.1038/s41598-018-26441-1.

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