Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story.
Bioanalysis. 2016.
PMID: 27460981
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Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story.
Bioanalysis. 2016 Aug;8(16):1645-62. doi: 10.4155/bio-2016-0094. Epub 2016 Jul 27.
Bioanalysis. 2016.
PMID: 27460981
Metabolites were detected and characterized using non-targeted MS/MS(ALL) with SWATH acquisition by a UHPLC-Q-TOF system. Results & methodology: Human MPCCs extensively metabolized LOR and formed 3-OH-DL-glucuronide (M13). Cross-species comparisons revealed monk …
Metabolites were detected and characterized using non-targeted MS/MS(ALL) with SWATH acquisition by a UHPLC-Q-TOF system. Resu …
In Vivo Metabolites of AB-PINACA in Solid Tissues Obtained from Its Abuser: Comparison with In Vitro Experiment.
J Anal Toxicol. 2021 Jan 21;44(9):1027-1035. doi: 10.1093/jat/bkaa031.
J Anal Toxicol. 2021.
PMID: 32232365
For in vitro experiment, AB-PINACA was incubated with human hepatocytes for 3 h to produce its metabolites. The identification of the in vivo and in vitro metabolites was performed using liquid chromatography (LC)-high-resolution Orbitrap-tandem mass spectrom …
For in vitro experiment, AB-PINACA was incubated with human hepatocytes for 3 h to produce its metabolites. The identification of the …
Re-Examining the Impact of Minimal Scans in Liquid Chromatography-Mass Spectrometry Analysis.
J Am Soc Mass Spectrom. 2021 Aug 4;32(8):2110-2122. doi: 10.1021/jasms.1c00073. Epub 2021 Jun 30.
J Am Soc Mass Spectrom. 2021.
PMID: 34190546
The fewer minimal scan prerequisite is presumably attributed to an improved LC system and advanced column technology, better MS detector, and more intelligent peak detection and integration algorithms leading to a more symmetric peak shape and smaller peak standard …
The fewer minimal scan prerequisite is presumably attributed to an improved LC system and advanced column technology, better MS …
Characterization and analysis of estrogenic cyclic phenone metabolites produced in vitro by rainbow trout liver slices using GC-MS, LC-MS and LC-TOF-MS.
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 15;1126-1127:121717. doi: 10.1016/j.jchromb.2019.121717. Epub 2019 Aug 11.
J Chromatogr B Analyt Technol Biomed Life Sci. 2019.
PMID: 31437775
Free PMC article.
In absence of standards, improved inference of CPK metabolites tentative structures was achieved by combining GC-MS with and without derivatization, LC with tandem MS, LC with high resolution time of flight (TOF) MS and LC fractionation data wit …
In absence of standards, improved inference of CPK metabolites tentative structures was achieved by combining GC-MS with and without …
Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Malar J. 2018 Aug 13;17(1):294. doi: 10.1186/s12936-018-2433-z.
Malar J. 2018.
PMID: 30103751
Free PMC article.
Knowledge of the metabolism of PQ is critical for understanding the therapeutic efficacy and hemolytic toxicity of this drug. Recent in vitro studies with primary human hepatocytes have been useful for developing the ultra high-performance liquid chromatography coupled wit …
Knowledge of the metabolism of PQ is critical for understanding the therapeutic efficacy and hemolytic toxicity of this drug. Recent in vitr …
Cytotoxic Lathyrane-Type Diterpenes from Seeds of Euphorbia lathyris.
Chem Pharm Bull (Tokyo). 2018 Jun 1;66(6):674-677. doi: 10.1248/cpb.c17-00946. Epub 2018 Mar 27.
Chem Pharm Bull (Tokyo). 2018.
PMID: 29593174
Free article.
We isolated two new lathyrane-type diterpenes L(27) (1) and L(28) (2) along with seven known compounds (3-9) from the seeds of Euphorbia lathyris. These compounds were identified by NMR, high-resolution electrospray ionisation (HR-ESI)-MS as well as IR spectr …
We isolated two new lathyrane-type diterpenes L(27) (1) and L(28) (2) along with seven known compounds (3-9) from the seeds of Euphorbia lat …
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