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Clin Hemorheol Microcirc. 2019 Jun 3. doi: 10.3233/CH-199104. [Epub ahead of print]

Adjuvant drug-assisted bone healing: Part III - Further strategies for local and systemic modulation.

Author information

1
Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
2
University Center of Orthopaedics and Traumatology (OUC), University Hospital Carl Gustav Carus, Dresden, Germany.
3
Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Faculty of Medicine, Technische Universit├Ąt Dresden, Dresden, Germany.
4
Center for Regenerative Therapies Dresden (CRTD), Tatzberg 4, Dresden.
5
Technische Universit├Ąt Dresden, School of Science, Faculty of Chemistry and Food Chemistry, Dresden, Germany.

Abstract

In this third in a series of reviews on adjuvant drug-assisted bone healing, further possibilities of influencing the healing process are discussed. Local and systemic modulation of bone metabolism is considered during use of a number of drugs with completely different indications, which are characterized by a pleiotropic spectrum of action. These include drugs used to treat lipid disorders (HMG-CoA reductase inhibitors), hypertension (ACE inhibitors), osteoporosis (bisphosphonates), cancer (proteasome inhibitors) and others. Possibilities of their application in the support of bone healing arediscussed.

KEYWORDS:

Bisphosphonates; Wnt signaling; bone metabolism; critical-size bone defects; small molecules; statins; strontium

PMID:
31177207
DOI:
10.3233/CH-199104

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