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Items: 1 to 20 of 45

1.

Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study.

Khodaverdian V, Tapadar S, MacDonald IA, Xu Y, Ho PY, Bridges A, Rajpurohit P, Sanghani BA, Fan Y, Thangaraju M, Hathaway NA, Oyelere AK.

Sci Rep. 2019 Mar 18;9(1):4802. doi: 10.1038/s41598-019-39214-1.

2.

Calliandra portoricensis Benth exhibits anticancer effects via alteration of Bax/Bcl-2 ratio and growth arrest in prostate LNCaP cells.

Oyebode OT, Owumi SE, Oyelere AK, Olorunsogo OO.

J Ethnopharmacol. 2019 Apr 6;233:64-72. doi: 10.1016/j.jep.2018.12.020. Epub 2018 Dec 21.

PMID:
30580026
3.

Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates.

Story S, Skriba MJ, Maiti K, Nihar Ranjan, Degtyareva NN, Green KD, Khodaverdian V, Oyelere AK, Garneau-Tsodikova S, Arya DP.

Eur J Med Chem. 2019 Feb 1;163:381-393. doi: 10.1016/j.ejmech.2018.11.022. Epub 2018 Nov 14.

PMID:
30530174
4.

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.

Xu J, Jia YF, Tapadar S, Weaver JD, Raji IO, Pithadia DJ, Javeed N, García AJ, Choi DS, Matveyenko AV, Oyelere AK, Shin CH.

Sci Rep. 2018 Oct 22;8(1):15587. doi: 10.1038/s41598-018-33875-0.

5.

Design, synthesis, and evaluation of the antiproliferative activity of hydantoin-derived antiandrogen-genistein conjugates.

George A, Raji I, Cinar B, Kucuk O, Oyelere AK.

Bioorg Med Chem. 2018 May 1;26(8):1481-1487. doi: 10.1016/j.bmc.2018.01.009. Epub 2018 Feb 16.

PMID:
29456113
6.

Toward the rational design of macrolide antibiotics to combat resistance.

Pavlova A, Parks JM, Oyelere AK, Gumbart JC.

Chem Biol Drug Des. 2017 Nov;90(5):641-652. doi: 10.1111/cbdd.13004. Epub 2017 May 16.

PMID:
28419786
7.

Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors.

Raji I, Ahluwalia K, Oyelere AK.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):744-749. doi: 10.1016/j.bmcl.2017.01.044. Epub 2017 Jan 17.

8.

Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone-Neomycin Conjugates.

Degtyareva NN, Gong C, Story S, Levinson NS, Oyelere AK, Green KD, Garneau-Tsodikova S, Arya DP.

ACS Infect Dis. 2017 Mar 10;3(3):206-215. doi: 10.1021/acsinfecdis.6b00176. Epub 2017 Feb 17.

9.

Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.

Raji I, Yadudu F, Janeira E, Fathi S, Szymczak L, Kornacki JR, Komatsu K, Li JD, Mrksich M, Oyelere AK.

Bioorg Med Chem. 2017 Feb 1;25(3):1202-1218. doi: 10.1016/j.bmc.2016.12.032. Epub 2016 Dec 24.

10.

Liposomal drug delivery systems for targeted cancer therapy: is active targeting the best choice?

Fathi S, Oyelere AK.

Future Med Chem. 2016 Nov;8(17):2091-2112. doi: 10.4155/fmc-2016-0135. Epub 2016 Oct 24.

PMID:
27774793
11.

A structure-activity relationship of non-peptide macrocyclic histone deacetylase inhibitors and their anti-proliferative and anti-inflammatory activities.

Tapadar S, Fathi S, Raji I, Omesiete W, Kornacki JR, Mwakwari SC, Miyata M, Mitsutake K, Li JD, Mrksich M, Oyelere AK.

Bioorg Med Chem. 2015 Dec 15;23(24):7543-64. doi: 10.1016/j.bmc.2015.10.045. Epub 2015 Nov 2.

12.

Determination of metal ion contents of two antiemetic clays use in Geophagy.

Owumi SE, Oyelere AK.

Toxicol Rep. 2015 Jun 16;2:928-932. doi: 10.1016/j.toxrep.2015.06.008. eCollection 2015.

13.

Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel.

Washington AZ, Tapadar S, George A, Oyelere AK.

Bioorg Med Chem. 2015 Aug 15;23(16):5198-209. doi: 10.1016/j.bmc.2015.04.078. Epub 2015 May 6.

14.

Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids.

Sodji QH, Kornacki JR, McDonald JF, Mrksich M, Oyelere AK.

Eur J Med Chem. 2015;96:340-59. doi: 10.1016/j.ejmech.2015.04.014. Epub 2015 Apr 8.

15.

Rapid synthesis, RNA binding, and antibacterial screening of a peptidic-aminosugar (PA) library.

Jiang L, Watkins D, Jin Y, Gong C, King A, Washington AZ, Green KD, Garneau-Tsodikova S, Oyelere AK, Arya DP.

ACS Chem Biol. 2015 May 15;10(5):1278-89. doi: 10.1021/cb5010367. Epub 2015 Feb 23.

16.

The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors.

Sodji Q, Patil V, Jain S, Kornacki JR, Mrksich M, Tekwani BL, Oyelere AK.

Bioorg Med Chem Lett. 2014 Oct 15;24(20):4826-30. doi: 10.1016/j.bmcl.2014.08.060. Epub 2014 Sep 4.

17.

Macrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome.

Washington AZ, Benicewicz DB, Canzoneri JC, Fagan CE, Mwakwari SC, Maehigashi T, Dunham CM, Oyelere AK.

ACS Chem Biol. 2014 Nov 21;9(11):2621-31. doi: 10.1021/cb5003224. Epub 2014 Sep 22.

18.

P-glycoprotein-dependent trafficking of nanoparticle-drug conjugates.

Dreaden EC, Raji IO, Austin LA, Fathi S, Mwakwari SC, Humphries WH 4th, Kang B, Oyelere AK, El-Sayed MA.

Small. 2014 May 14;10(9):1719-23. doi: 10.1002/smll.201303190. Epub 2014 Feb 25. No abstract available.

19.

Synthesis and structure-activity relationship of 3-hydroxypyridine-2-thione-based histone deacetylase inhibitors.

Sodji QH, Patil V, Kornacki JR, Mrksich M, Oyelere AK.

J Med Chem. 2013 Dec 27;56(24):9969-81. doi: 10.1021/jm401225q. Epub 2013 Dec 12.

20.

Selectively targeting prostate cancer with antiandrogen equipped histone deacetylase inhibitors.

Gryder BE, Akbashev MJ, Rood MK, Raftery ED, Meyers WM, Dillard P, Khan S, Oyelere AK.

ACS Chem Biol. 2013 Nov 15;8(11):2550-60. doi: 10.1021/cb400542w. Epub 2013 Sep 20.

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