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Antioxidants (Basel). 2019 Dec 17;8(12). pii: E650. doi: 10.3390/antiox8120650.

Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort.

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Pôle Neurosciences Cliniques, Centre Hospitalier Universitaire de Bordeaux, F-33076 Bordeaux, France.
Sommeil, Addiction et NeuroPSYchiatrie, Université de Bordeaux, CNRS, SANPSY, USR 3413, F-33000 Bordeaux, France.
Centre d'Investigation Clinique Bordeaux, INSERM CIC 1401, Centre Hospitalier Universitaire de Bordeaux, F-33000 Bordeaux, France.
Vascular Medicine Service, Centre Hospitalier Universitaire de Bordeaux, F-33000 Bordeaux, France.
Activ'Inside, F-33750 Beychac et Caillau, France.
Department of Food & Drugs, University of Parma, 43125 Parma, Italy.
Department of Veterinary Science, University of Parma, 43125 Parma, Italy.
School of Advanced Studies on Food and Nutrition, University of Parma, 43125 Parma, Italy.
Microbiome Research Hub, University of Parma, 43124 Parma, Italy.
Norwich Medical School, Biomedical Research Centre, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich NR4 7TJ, UK.


Despite an increasing level of evidence supporting the individual beneficial effect of polyphenols on cognitive performance, information related to the potential synergistic action of these phytonutrients on cognitive performance during a prolonged cognitive effort is currently lacking. This study investigated the acute and sustained action of a polyphenols-rich extract from grape and blueberry (PEGB), on working memory and attention in healthy students during a prolonged and intensive cognitive effort. In this randomised, cross-over, double blind study, 30 healthy students consumed 600 mg of PEGB or a placebo. Ninety minutes after product intake, cognitive functions were assessed for one hour using a cognitive demand battery including serial subtraction tasks, a rapid visual information processing (RVIP) task and a visual analogical scale. Flow-mediated dilation (FMD) and plasma flavan-3-ols metabolites quantification were also performed. A 2.5-fold increase in serial three subtraction variation net scores was observed following PEGB consumption versus placebo (p < 0.001). A trend towards significance was also observed with RVIP percentage of correct answers (p = 0.058). No treatment effect was observed on FMD. Our findings suggest that consumption of PEGB coupled with a healthy lifestyle may be a safe alternative to acutely improve working memory and attention during a sustained cognitive effort.


brain; catechin; cognition; epicatechin; flavanols; flavonoids; human; monomers; single dose

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